Format

Send to:

Choose Destination
    • Showing Current items.

    HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 [ Homo sapiens (human) ]

    Gene ID: 3181, updated on 11-Jul-2021

    Summary

    Official Symbol
    HNRNPA2B1provided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A2/B1provided by HGNC
    Primary source
    HGNC:HGNC:5033
    See related
    Ensembl:ENSG00000122566 MIM:600124
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNPA2; HNRPA2; HNRPB1; SNRPB1; HNRNPA2; HNRNPB1; IBMPFD2; HNRPA2B1
    Summary
    This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 202.7), appendix (RPKM 193.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HNRNPA2B1 in Genome Data Viewer
    Location:
    7p15.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (26189920..26200775, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (26229547..26240366, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375199 Neighboring gene uncharacterized LOC105375198 Neighboring gene nuclear factor, erythroid 2 like 3 Neighboring gene Sharpr-MPRA regulatory region 4449 Neighboring gene chromobox 3 Neighboring gene ribosomal protein L23 pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    env Depletion of hnRNP A1 and A2 increase expression of viral structural proteins Gag, Env, and gp120 PubMed
    Envelope surface glycoprotein gp160, precursor env Depletion of hnRNP A1 and A2 increase expression of viral structural proteins Gag, Env, and gp120 PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag Depletion of hnRNP A1 and A2 increase expression of viral structural proteins Gag, Env, and gp120 PubMed
    Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa. The interaction of Rev with HNRNPA2B1 is increased by RRE PubMed
    Tat tat Expression of HIV-1 Tat downregulates the abundance of heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) in the nucleoli of Jurkat T-cells PubMed
    Vif vif Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G13-2: AGGGA) to regulate the levels of vif and vpr mRNA, and the amounts of Vif and Vpr protein expression PubMed
    vif Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G12-1: AGGGA) to regulate the levels of vif mRNA and Vif protein expression PubMed
    Vpr vpr Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G13-2: AGGGA) to regulate the levels of vif and vpr mRNA, and the amounts of Vif and Vpr protein expression PubMed
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies translation regulatory and RNA binding proteins eIF3h, eEF1A-1, and hnRNPA2 as IN-binding partners PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) at amino acid residues 135-136 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ22720, DKFZp779B0244

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-rich strand telomeric DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables N6-methyladenosine-containing RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Cajal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    located_in nuclear matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoproteins A2/B1
    Names
    HNRNPA2B1/MYC fusion
    epididymis secretory sperm binding protein
    hnRNP A2 / hnRNP B1
    nuclear ribonucleoprotein particle A2 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029680.1 RefSeqGene

      Range
      5048..15867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002137.4NP_002128.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2

      See identical proteins and their annotated locations for NP_002128.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A2) lacks 36 bases at the beginning of the coding region compared to variant B1. The N-terminus of isoform A2 is thus different from isoform B1. This isoform (A2) is the predominant protein.
      Source sequence(s)
      AC004520, DB244417, M29065
      Consensus CDS
      CCDS5397.1
      UniProtKB/Swiss-Prot
      P22626
      Related
      ENSP00000478691.2, ENST00000618183.5
      Conserved Domains (3) summary
      pfam11627
      Location:290314
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    2. NM_031243.3NP_112533.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform B1

      See identical proteins and their annotated locations for NP_112533.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B1) contains an additional 36 bases compared to variant A2. This additional region affects only the beginning of the coding region. The N-terminus of isoform B1 is thus different from isoform A2.
      Source sequence(s)
      AC004520, DB244417, M29064
      Consensus CDS
      CCDS43557.1
      UniProtKB/Swiss-Prot
      P22626
      Related
      ENSP00000346694.4, ENST00000354667.8
      Conserved Domains (3) summary
      pfam11627
      Location:302326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      26189920..26200775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012109.2XP_016867598.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

      UniProtKB/Swiss-Prot
      P22626
      Related
      ENSP00000503060.1, ENST00000677656.1
      Conserved Domains (3) summary
      pfam11627
      Location:290314
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    2. XM_005249729.1XP_005249786.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

      See identical proteins and their annotated locations for XP_005249786.1

      UniProtKB/Swiss-Prot
      P22626
      Related
      ENSP00000354021.4, ENST00000360787.8
      Conserved Domains (3) summary
      pfam11627
      Location:302326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
    3. XM_017012110.2XP_016867599.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

      UniProtKB/Swiss-Prot
      P22626
      Related
      ENSP00000503429.1, ENST00000678779.1
      Conserved Domains (3) summary
      pfam11627
      Location:290314
      HnRNPA1; Nuclear factor hnRNPA1
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

    RNA

    1. XR_242077.2 RNA Sequence

    2. XR_001744666.2 RNA Sequence

    3. XR_001744673.2 RNA Sequence

    4. XR_001744674.2 RNA Sequence

    5. XR_002956424.1 RNA Sequence

    6. XR_001744675.1 RNA Sequence

    7. XR_242076.1 RNA Sequence

    8. XR_428077.1 RNA Sequence

    9. XR_001744665.1 RNA Sequence

    10. XR_002956425.1 RNA Sequence

    11. XR_001744671.2 RNA Sequence

    12. XR_001744672.2 RNA Sequence

    13. XR_001744670.2 RNA Sequence

    14. XR_001744663.1 RNA Sequence

    15. XR_001744664.1 RNA Sequence

    16. XR_001744662.1 RNA Sequence

    17. XR_001744668.2 RNA Sequence

    18. XR_001744667.2 RNA Sequence

    19. XR_001744669.2 RNA Sequence

    Support Center