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    Inx2 Innexin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31646, updated on 18-Sep-2024

    Summary

    Official Symbol
    Inx2provided by FlyBase
    Official Full Name
    Innexin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0027108
    Locus tag
    Dmel_CG4590
    See related
    AllianceGenome:FB:FBgn0027108
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4590; D-inx-2; Dm-inx; Dm-inx2; Dm-Inx2; Dmel\CG4590; FBpp0291074; inx-2; Inx-2; INX-2; inx2; Ix2; kropf; l(1)G0035; l(1)G0036; l(1)G0043; l(1)G0059; l(1)G0118; l(1)G0157; l(1)G0317; l(1)G0364; prp33
    Summary
    Enables gap junction channel activity. Involved in several processes, including foregut morphogenesis; gamete generation; and male germ-line stem cell population maintenance. Located in apical plasma membrane; apicolateral plasma membrane; and gap junction. Is expressed in several structures, including epithelium; extended germ band embryo; gut section; ovariole; and trunk ectoderm. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See Inx2 in Genome Data Viewer
    Location:
    6E4-6E4; 1-18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6998672..7004151)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6892705..6898184)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Innexin 7 Neighboring gene long non-coding RNA:CR43837 Neighboring gene carmine Neighboring gene sloth 1 Neighboring gene sloth 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables gap junction channel activity IC
    Inferred by Curator
    more info
    PubMed 
    enables gap junction channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    innexin 2
    Names
    CG4590-PA
    CG4590-PB
    CG4590-PC
    CG4590-PD
    Innexin-2
    Inx2-PA
    Inx2-PB
    Inx2-PC
    Inx2-PD
    innexin
    innexin2
    pas related protein 33

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6998672..7004151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272372.1NP_001259301.1  innexin 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259301.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V431, Q9V427
      UniProtKB/TrEMBL
      E1JJF3
      Conserved Domains (1) summary
      cl03000
      Location:1351
      Innexin; Innexin
    2. NM_167104.3NP_727150.1  innexin 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727150.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V431, Q9V427
      UniProtKB/TrEMBL
      E1JJF3
      Related
      FBpp0070966
      Conserved Domains (1) summary
      cl03000
      Location:1351
      Innexin; Innexin
    3. NM_132147.4NP_572375.1  innexin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572375.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V431, Q9V427
      UniProtKB/TrEMBL
      E1JJF3
      Related
      FBpp0070965
      Conserved Domains (1) summary
      cl03000
      Location:1351
      Innexin; Innexin
    4. NM_001169213.2NP_001162684.1  innexin 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162684.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V431, Q9V427
      UniProtKB/TrEMBL
      E1JJF3
      Conserved Domains (1) summary
      cl03000
      Location:1351
      Innexin; Innexin