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    HMOX2 heme oxygenase 2 [ Homo sapiens (human) ]

    Gene ID: 3163, updated on 17-Jun-2024

    Summary

    Official Symbol
    HMOX2provided by HGNC
    Official Full Name
    heme oxygenase 2provided by HGNC
    Primary source
    HGNC:HGNC:5014
    See related
    Ensembl:ENSG00000103415 MIM:141251; AllianceGenome:HGNC:5014
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HO-2
    Summary
    Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
    Expression
    Ubiquitous expression in testis (RPKM 23.0), brain (RPKM 16.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HMOX2 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4474736..4510347)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4504257..4539822)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4524737..4560348)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903635 Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4499977-4500772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4505719-4506689 Neighboring gene MPRA-validated peak2472 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4516031-4516532 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4526195-4526696 Neighboring gene NmrA like redox sensor 1 Neighboring gene uncharacterized LOC124903636 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:4543888-4544077 Neighboring gene Sharpr-MPRA regulatory region 9698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4563218-4563745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4563746-4564272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4564273-4564800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4571909-4572773 Neighboring gene cell death inducing p53 target 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4579080-4579732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4579733-4580384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7153 Neighboring gene chromosome 16 open reading frame 96 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4604203-4604813 Neighboring gene SUB1 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme oxygenase (decyclizing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme oxygenase (decyclizing) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in heme catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heme oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    heme oxygenase 2
    Names
    heme oxygenase (decycling) 2
    NP_001120676.1
    NP_001120677.1
    NP_001120678.1
    NP_001273196.1
    NP_001273197.1
    NP_001273198.1
    NP_001273199.1
    NP_001273200.1
    NP_002125.3
    XP_016878685.1
    XP_024306018.1
    XP_054185152.1
    XP_054185153.1
    XP_054236180.1
    XP_054236181.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127204.2NP_001120676.1  heme oxygenase 2 isoform b

      See identical proteins and their annotated locations for NP_001120676.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
      Source sequence(s)
      BC002396, D21243, DA141643, DA694137
      Consensus CDS
      CCDS10517.1
      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2
      Related
      ENSP00000394103.3, ENST00000458134.7
      Conserved Domains (2) summary
      cd19165
      Location:147174
      HemeO; kinked helix [structural motif]
      pfam01126
      Location:31236
      Heme_oxygenase; Heme oxygenase
    2. NM_001127205.2NP_001120677.1  heme oxygenase 2 isoform b

      See identical proteins and their annotated locations for NP_001120677.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
      Source sequence(s)
      BC002396, BP368949, D21243
      Consensus CDS
      CCDS10517.1
      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2
      Related
      ENSP00000391637.1, ENST00000414777.5
      Conserved Domains (2) summary
      cd19165
      Location:147174
      HemeO; kinked helix [structural motif]
      pfam01126
      Location:31236
      Heme_oxygenase; Heme oxygenase
    3. NM_001127206.3NP_001120678.1  heme oxygenase 2 isoform b

      See identical proteins and their annotated locations for NP_001120678.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
      Source sequence(s)
      BC002396, BE561721
      Consensus CDS
      CCDS10517.1
      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2
      Related
      ENSP00000385100.2, ENST00000406590.6
      Conserved Domains (2) summary
      cd19165
      Location:147174
      HemeO; kinked helix [structural motif]
      pfam01126
      Location:31236
      Heme_oxygenase; Heme oxygenase
    4. NM_001286267.2NP_001273196.1  heme oxygenase 2 isoform a

      See identical proteins and their annotated locations for NP_001273196.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (a).
      Source sequence(s)
      BC002396, DA141643
      Consensus CDS
      CCDS73818.1
      UniProtKB/TrEMBL
      A0A087WT44, B3KSE0, Q6FHB5, Q6IBP2
      Related
      ENSP00000477572.1, ENST00000613539.1
      Conserved Domains (1) summary
      pfam01126
      Location:85290
      Heme_oxygenase; Heme oxygenase
    5. NM_001286268.2NP_001273197.1  heme oxygenase 2 isoform b

      See identical proteins and their annotated locations for NP_001273197.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
      Source sequence(s)
      BC002396, DA141643, DB184091
      Consensus CDS
      CCDS10517.1
      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2
      Related
      ENSP00000484467.1, ENST00000619913.4
      Conserved Domains (2) summary
      cd19165
      Location:147174
      HemeO; kinked helix [structural motif]
      pfam01126
      Location:31236
      Heme_oxygenase; Heme oxygenase
    6. NM_001286269.2NP_001273198.1  heme oxygenase 2 isoform b

      See identical proteins and their annotated locations for NP_001273198.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
      Source sequence(s)
      BC002396, BP329113, DA141643
      Consensus CDS
      CCDS10517.1
      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2
      Related
      ENSP00000484423.1, ENST00000619528.4
      Conserved Domains (2) summary
      cd19165
      Location:147174
      HemeO; kinked helix [structural motif]
      pfam01126
      Location:31236
      Heme_oxygenase; Heme oxygenase
    7. NM_001286270.2NP_001273199.1  heme oxygenase 2 isoform b

      See identical proteins and their annotated locations for NP_001273199.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
      Source sequence(s)
      AK093388, BC002396
      Consensus CDS
      CCDS10517.1
      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2
      Related
      ENSP00000381595.3, ENST00000398595.7
      Conserved Domains (2) summary
      cd19165
      Location:147174
      HemeO; kinked helix [structural motif]
      pfam01126
      Location:31236
      Heme_oxygenase; Heme oxygenase
    8. NM_001286271.2NP_001273200.1  heme oxygenase 2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      BC002396, BM905872, DA141643
      Consensus CDS
      CCDS66931.1
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2
      Related
      ENSP00000460926.1, ENST00000575120.5
      Conserved Domains (1) summary
      pfam01126
      Location:2207
      Heme_oxygenase; Heme oxygenase
    9. NM_002134.4NP_002125.3  heme oxygenase 2 isoform b

      See identical proteins and their annotated locations for NP_002125.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 4, 6, 7, and 8 all encode the same isoform (b).
      Source sequence(s)
      BC002396, DA141643
      Consensus CDS
      CCDS10517.1
      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2
      Related
      ENSP00000459214.1, ENST00000570646.6
      Conserved Domains (2) summary
      cd19165
      Location:147174
      HemeO; kinked helix [structural motif]
      pfam01126
      Location:31236
      Heme_oxygenase; Heme oxygenase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      4474736..4510347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023196.3XP_016878685.1  heme oxygenase 2 isoform X1

      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2
      Conserved Domains (2) summary
      cd19165
      Location:147174
      HemeO; kinked helix [structural motif]
      pfam01126
      Location:31236
      Heme_oxygenase; Heme oxygenase
    2. XM_024450250.2XP_024306018.1  heme oxygenase 2 isoform X1

      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2
      Conserved Domains (2) summary
      cd19165
      Location:147174
      HemeO; kinked helix [structural motif]
      pfam01126
      Location:31236
      Heme_oxygenase; Heme oxygenase

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187608.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      177059..212670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329177.1XP_054185152.1  heme oxygenase 2 isoform X1

      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2
    2. XM_054329178.1XP_054185153.1  heme oxygenase 2 isoform X1

      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      4504257..4539822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380205.1XP_054236180.1  heme oxygenase 2 isoform X1

      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2
    2. XM_054380206.1XP_054236181.1  heme oxygenase 2 isoform X1

      UniProtKB/Swiss-Prot
      A8MT35, D3DUD5, I3L430, O60605, P30519
      UniProtKB/TrEMBL
      B3KSE0, Q6FHB5, Q6IBP2