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    HMOX1 heme oxygenase 1 [ Homo sapiens (human) ]

    Gene ID: 3162, updated on 2-Aug-2021

    Summary

    Official Symbol
    HMOX1provided by HGNC
    Official Full Name
    heme oxygenase 1provided by HGNC
    Primary source
    HGNC:HGNC:5013
    See related
    Ensembl:ENSG00000100292 MIM:141250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HO-1; HSP32; HMOX1D; bK286B10
    Summary
    Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 208.2), ovary (RPKM 68.8) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HMOX1 in Genome Data Viewer
    Location:
    22q12.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (35381096..35394207)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (35777089..35790200)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene target of myb1 membrane trafficking protein Neighboring gene microRNA 3909 Neighboring gene microRNA 6069 Neighboring gene minichromosome maintenance complex component 5 Neighboring gene tRNA methyltransferase 11 homolog (S. cerevisiae) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    COPD, severe early-onset
    MedGen: C1969833 OMIM: 606963 GeneReviews: Not available
    Compare labs
    Heme oxygenase 1 deficiency
    MedGen: C1841651 OMIM: 614034 GeneReviews: Not available
    Compare labs
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 (BAL-1, Jago, SF162, YU2, ADA, 89.6, Doge, JR-CSF, BL-3, JRFL and HIV-2 TYBE) replication decreases HMOX1 expression in monocyte-derived macrophages; extent of replication appears to be proportional to extent HMOX1 deficiency PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 significantly upregulates Nrf2 in human astrocytes and is associated with increased levels of key antioxidant defensive enzymes Hemoxygenase (HO-1) and NAD(P)H dehydrogenase quinone1 (Nqo1) PubMed
    Nef nef HMOX1 mRNA is selectively retained in HIV-1 Nef-expressing cellular exosomes, and five miRNAs (miR-15b, miR-26b*, miR-125b, let-7a, and let-7e*) which target HMOX1 mRNA are selectively secreted in exosomes from these cells PubMed
    Tat tat HIV-1 Tat upregulates NQO1, CAT, SOD1, SOD2, and HMOX1 (HO1) mRNA levels in SH-SY5Y cells PubMed
    tat HO-1 modulates the inhibitory effect of celastro on HIV-1 Tat-induced upregulation of ICAM-1 and VCAM-1, and release of CXCL10, IL-8, and MCP-1 in human astroglioma cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heme oxygenase (decyclizing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables heme oxygenase (decyclizing) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heme oxygenase (decyclizing) activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cisplatin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in erythrocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in excretion IC
    Inferred by Curator
    more info
    PubMed 
    involved_in heme catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in heme catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heme oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in heme oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in liver regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in low-density lipoprotein particle clearance TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of leukocyte migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mast cell cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
    involved_in positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of chemokine production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription from RNA polymerase II promoter in response to iron IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hydrogen peroxide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to nicotine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smooth muscle hyperplasia TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in wound healing involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heme oxygenase 1
    Names
    heat shock protein, 32-kD
    heme oxygenase (decycling) 1
    NP_002124.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023030.1 RefSeqGene

      Range
      5030..18141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002133.3NP_002124.1  heme oxygenase 1

      See identical proteins and their annotated locations for NP_002124.1

      Status: REVIEWED

      Source sequence(s)
      BP288767, CA306357, X06985
      Consensus CDS
      CCDS13914.1
      UniProtKB/Swiss-Prot
      P09601
      UniProtKB/TrEMBL
      Q6FH11
      Related
      ENSP00000216117.8, ENST00000216117.9
      Conserved Domains (1) summary
      pfam01126
      Location:11216
      Heme_oxygenase; Heme oxygenase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      35381096..35394207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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