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    HLA-G major histocompatibility complex, class I, G [ Homo sapiens (human) ]

    Gene ID: 3135, updated on 16-Apr-2024

    Summary

    Official Symbol
    HLA-Gprovided by HGNC
    Official Full Name
    major histocompatibility complex, class I, Gprovided by HGNC
    Primary source
    HGNC:HGNC:4964
    See related
    Ensembl:ENSG00000204632 MIM:142871; AllianceGenome:HGNC:4964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MHC-G
    Summary
    HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 29.5), colon (RPKM 14.0) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    6p22.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (29826474..29831021)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (29698275..29702836)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29794251..29798798)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29780458-29781338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29782298-29782798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29782799-29783299 Neighboring gene MHC class I polypeptide-related sequence G (pseudogene) Neighboring gene HLA complex group 4 pseudogene 8 Neighboring gene HCGVIII-2 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:29812738-29813937 Neighboring gene uncharacterized LOC105375010 Neighboring gene Sharpr-MPRA regulatory region 7378 Neighboring gene MHC class I polypeptide-related sequence F (pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Inherited susceptibility to asthma
    MedGen: C1869116 OMIM: 600807 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
    EBI GWAS Catalog
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
    env Conformational changes in HIV-1 gp120, including an enhanced expression of the V3 loop of gp120 and of epitopes that are exposed upon CD4 binding, are consistent with the formation of a multimolecular complex between HLA class I and gp120/160 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-derived peptide p18 presented by H-2Dd class I major histocompatibility complex molecules is processed by angiotensin-1 converting enzyme (ACE) prior to T cell stimulation by the peptide p18 PubMed
    Envelope transmembrane glycoprotein gp41 env Soluble HIV-1 gp41 can selectively enhance MHC class I and II expression on human B cells, but does not increase expression of other cell surface antigens such as CD21 and CD54 (ICAM-1) PubMed
    env Soluble HIV-1 gp41 enhancement effects on MHC class I and II antigen expression can be inhibited by soluble gp41-binding proteins of 45, 49 and 62 kD from human B cells PubMed
    env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed
    Nef nef HIV-1 Nef downregulates the expression of MHC-I at the surface of lymphoid, monocytic and epithelial cells, causing MHC-I molecules to be rapidly internalized, accumulated in endosomal vesicles and degraded PubMed
    nef Double (W13A/V16R) and triple (W13A/V16R/M20A) substitution mutants of HIV-1 Nef fail to downregulate MHC-I PubMed
    nef HIV-1 Nef-mediated downregulation of MHC-I requires Nef motif EEEE(65)-dependent binding to the sorting protein PACS-2, which targets Nef to the paranuclear region and enables Nef PXXP(75) to bind and activate a trans-Golgi network localized Src kinase PubMed
    nef HIV-1 Nef-induced downregulation of MHC-I expression and MHC-I targeting to the trans-Golgi network (TGN) require the binding of Nef to PACS-1, a molecule that controls the TGN localization of the cellular protein furin PubMed
    nef HIV-1 Nef downregulates expression of MHC-I by blocking transport of MHC-I molecules to the cell surface through a mechanism that requires phosphoinositide 3-kinase (PI 3-kinase) activity PubMed
    nef Interaction of HIV-1 Nef with the mu subunit of AP adaptor complexes requires the recognition of tyrosine-based sorting signals, which likely facilitates the connection between MHC I and the clathrin-dependent sorting machinery PubMed
    nef A methionine residue at amino acid 20 in the alpha-helix domain is required for the ability of HIV-1 Nef to downregulate MHC-I expression but not for the downregulation of CD4 PubMed
    nef Four glutamic acids from position 62 to 65 in the SH3 domain of HIV-1 Nef bind to the cytoplasmic tail at position 320Y of MHC-I, and are required for the Nef-mediated downregulation of MHC-I from the cell surface PubMed
    nef Amino acid residue Y320 in the MHC-I cytoplasmic domain and residues E62-65 and P78 in HIV-1 Nef are required for interaction with the mu subunit of AP-1 PubMed
    nef MHC-I is found in the Rab7(+) vesicles and is targeted for degradation via the activity of the Nef-interacting protein, beta-COP PubMed
    nef Deletion of the 19 N-terminal amino acids including the myristoylation signal from HIV-1 Nef inhibits both MHC-I and CD4 downregulation while preserving most CTL, T-helper and B-cell epitopes PubMed
    nef HLA-G, which is mainly expressed in placental tissues and in thymic epithelial cells, resists Nef-induced cell surface downregulation as a result of its short intracytoplasmic domain PubMed
    Tat tat HIV-1 Tat 47-59 peptide downregulates gene expression of HLA-G histocompatibility antigen, class I, G (HLA-G) in U-937 macrophages PubMed
    tat HIV-1 Tat upregulates MHC class I in monocyte-derived dendritic cells and CD8(+) T cells, thereby driving T cell-mediated immune responses PubMed
    tat HIV-1 Tat represses the MHC class I gene promoter by binding to and repressing TAFII250, a component of the general transcription factor TFIID, suggesting a mechanism for HIV-1 to downregulate MHC class I expression and avoid immune surveillance PubMed
    Vpu vpu HLA class I-associated immune responses have minor effects on Vpu variability, suggesting that Vpu conformation and function are preserved through many possible combinations of primary and secondary polymorphisms PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CD8 receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide antigen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response-inhibiting cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of G0 to G1 transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of T cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of immune response IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peripheral B cell tolerance induction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of T cell tolerance induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cellular senescence IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macrophage cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of natural killer cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of tolerance induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protection from natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein homotrimerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    part_of MHC class I protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cis-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in filopodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lumenal side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    located_in phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in recycling endosome membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    HLA class I histocompatibility antigen, alpha chain G
    Names
    HLA G antigen
    HLA-G histocompatibility antigen, class I, G
    MHC class I antigen G
    MHC class I protein
    MHC class Ib antigen
    b2 microglobulin
    mutant MHC class I antigen
    mutant MHC class Ib antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029039.1 RefSeqGene

      Range
      5847..9043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001363567.2NP_001350496.1  HLA class I histocompatibility antigen, alpha chain G isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL645929
      Consensus CDS
      CCDS87380.1
      UniProtKB/TrEMBL
      A0A024RCI4, A0A0G2JPQ3, Q5RJ85
      Related
      ENSP00000366024.2, ENST00000376828.6
      Conserved Domains (2) summary
      pfam00129
      Location:30208
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cd21022
      Location:211303
      IgC1_MHC_Ia_HLA-G; Class Ib major histocompatibility complex (MHC) immunoglobulin domain of human leukocyte antigen (HLA) G; member of the C1-set of Ig superfamily (IgSF) domains
    2. NM_001384280.1NP_001371209.1  HLA class I histocompatibility antigen, alpha chain G isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL645929, AL645939
      Consensus CDS
      CCDS87380.1
      UniProtKB/TrEMBL
      A0A024RCI4, A0A0G2JPQ3, Q5RJ85
      Conserved Domains (2) summary
      pfam00129
      Location:30208
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cd21022
      Location:211303
      IgC1_MHC_Ia_HLA-G; Class Ib major histocompatibility complex (MHC) immunoglobulin domain of human leukocyte antigen (HLA) G; member of the C1-set of Ig superfamily (IgSF) domains
    3. NM_001384290.1NP_001371219.1  HLA class I histocompatibility antigen, alpha chain G isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL645929
      Consensus CDS
      CCDS4668.1
      UniProtKB/Swiss-Prot
      P17693
      UniProtKB/TrEMBL
      A0A1V0E3X1, A0A5Q2WTV3, A0A890BW29, E5DHS1, Q30182, Q6DU14, Q8MGQ7, Q8MH47
      Related
      ENSP00000353472.6, ENST00000360323.11
      Conserved Domains (2) summary
      pfam00129
      Location:25203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cd21022
      Location:206298
      IgC1_MHC_Ia_HLA-G; Class Ib major histocompatibility complex (MHC) immunoglobulin domain of human leukocyte antigen (HLA) G; member of the C1-set of Ig superfamily (IgSF) domains
    4. NM_002127.6NP_002118.1  HLA class I histocompatibility antigen, alpha chain G isoform 2 precursor

      See identical proteins and their annotated locations for NP_002118.1

      Status: REVIEWED

      Source sequence(s)
      AL645929
      Consensus CDS
      CCDS4668.1
      UniProtKB/Swiss-Prot
      P17693
      UniProtKB/TrEMBL
      A0A1V0E3X1, A0A5Q2WTV3, A0A890BW29, E5DHS1, Q30182, Q6DU14, Q8MGQ7, Q8MH47
      Conserved Domains (2) summary
      pfam00129
      Location:25203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cd21022
      Location:206298
      IgC1_MHC_Ia_HLA-G; Class Ib major histocompatibility complex (MHC) immunoglobulin domain of human leukocyte antigen (HLA) G; member of the C1-set of Ig superfamily (IgSF) domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      29826474..29831021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418722.1XP_047274678.1  HLA class I histocompatibility antigen, alpha chain G isoform X1

      Related
      ENSP00000366014.3, ENST00000376818.7
    2. XM_017010818.2XP_016866307.2  HLA class I histocompatibility antigen, alpha chain G isoform X1

    3. XM_024446420.2XP_024302188.2  HLA class I histocompatibility antigen, alpha chain G isoform X2

      UniProtKB/TrEMBL
      A0A024RCI4, Q5RJ85

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1092086..1096756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328500.1XP_054184475.1  HLA class I histocompatibility antigen, alpha chain G isoform X4

      UniProtKB/TrEMBL
      Q8MH48
    2. XM_054328501.1XP_054184476.1  HLA class I histocompatibility antigen, alpha chain G isoform X3

      UniProtKB/TrEMBL
      A0A0G2JNX1
    3. XM_054328502.1XP_054184477.1  HLA class I histocompatibility antigen, alpha chain G isoform X3

      UniProtKB/TrEMBL
      A0A0G2JNX1
    4. XM_054328499.1XP_054184474.1  HLA class I histocompatibility antigen, alpha chain G isoform X4

      UniProtKB/TrEMBL
      Q8MH48

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1310036..1314706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329820.1XP_054185795.1  HLA class I histocompatibility antigen, alpha chain G isoform X4

      UniProtKB/Swiss-Prot
      P17693
      UniProtKB/TrEMBL
      Q6DU14
    2. XM_054329821.1XP_054185796.1  HLA class I histocompatibility antigen, alpha chain G isoform X5

      UniProtKB/TrEMBL
      Q31611
    3. XM_054329819.1XP_054185794.1  HLA class I histocompatibility antigen, alpha chain G isoform X4

      UniProtKB/Swiss-Prot
      P17693
      UniProtKB/TrEMBL
      Q6DU14
    4. XM_054329822.1XP_054185797.1  HLA class I histocompatibility antigen, alpha chain G isoform X5

      UniProtKB/TrEMBL
      Q31611

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      1089287..1093834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330306.1XP_054186281.1  HLA class I histocompatibility antigen, alpha chain G isoform X1

    2. XM_054330307.1XP_054186282.1  HLA class I histocompatibility antigen, alpha chain G isoform X1

    3. XM_054330305.1XP_054186280.1  HLA class I histocompatibility antigen, alpha chain G isoform X2

      UniProtKB/TrEMBL
      A0A024RCI4, Q5RJ85

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      1088961..1093507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330602.1XP_054186577.1  HLA class I histocompatibility antigen, alpha chain G isoform X1

    2. XM_054330603.1XP_054186578.1  HLA class I histocompatibility antigen, alpha chain G isoform X1

    3. XM_054330601.1XP_054186576.1  HLA class I histocompatibility antigen, alpha chain G isoform X2

      UniProtKB/TrEMBL
      A0A024RCI4, Q5RJ85
    4. XM_054330600.1XP_054186575.1  HLA class I histocompatibility antigen, alpha chain G isoform X6

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      1088945..1093492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330821.1XP_054186796.1  HLA class I histocompatibility antigen, alpha chain G isoform X1

    2. XM_054330822.1XP_054186797.1  HLA class I histocompatibility antigen, alpha chain G isoform X1

    3. XM_054330820.1XP_054186795.1  HLA class I histocompatibility antigen, alpha chain G isoform X2

      UniProtKB/TrEMBL
      A0A024RCI4, Q5RJ85
    4. XM_054330819.1XP_054186794.1  HLA class I histocompatibility antigen, alpha chain G isoform X7

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      1089240..1093910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331074.1XP_054187049.1  HLA class I histocompatibility antigen, alpha chain G isoform X4

      UniProtKB/Swiss-Prot
      P17693
      UniProtKB/TrEMBL
      Q6DU14
    2. XM_054331075.1XP_054187050.1  HLA class I histocompatibility antigen, alpha chain G isoform X9

      UniProtKB/TrEMBL
      Q31611
    3. XM_054331073.1XP_054187048.1  HLA class I histocompatibility antigen, alpha chain G isoform X4

      UniProtKB/Swiss-Prot
      P17693
      UniProtKB/TrEMBL
      Q6DU14
    4. XM_054331076.1XP_054187051.1  HLA class I histocompatibility antigen, alpha chain G isoform X9

      UniProtKB/TrEMBL
      Q31611
    5. XM_054331072.1XP_054187047.1  HLA class I histocompatibility antigen, alpha chain G isoform X8

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      1132505..1137175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331339.1XP_054187314.1  HLA class I histocompatibility antigen, alpha chain G isoform X4

      UniProtKB/Swiss-Prot
      P17693
      UniProtKB/TrEMBL
      Q6DU14
    2. XM_054331340.1XP_054187315.1  HLA class I histocompatibility antigen, alpha chain G isoform X10

      UniProtKB/TrEMBL
      Q31611
    3. XM_054331338.1XP_054187313.1  HLA class I histocompatibility antigen, alpha chain G isoform X4

      UniProtKB/Swiss-Prot
      P17693
      UniProtKB/TrEMBL
      Q6DU14
    4. XM_054331341.1XP_054187316.1  HLA class I histocompatibility antigen, alpha chain G isoform X10

      UniProtKB/TrEMBL
      Q31611

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      29698275..29702836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355312.1XP_054211287.1  HLA class I histocompatibility antigen, alpha chain G isoform X12

    2. XM_054355313.1XP_054211288.1  HLA class I histocompatibility antigen, alpha chain G isoform X1

    3. XM_054355314.1XP_054211289.1  HLA class I histocompatibility antigen, alpha chain G isoform X1

    4. XM_054355311.1XP_054211286.1  HLA class I histocompatibility antigen, alpha chain G isoform X4

      UniProtKB/TrEMBL
      Q8MH48
    5. XM_054355310.1XP_054211285.1  HLA class I histocompatibility antigen, alpha chain G isoform X11