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    bcn92 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31186, updated on 11-Apr-2024

    Summary

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    Official Symbol
    bcn92provided by FlyBase
    Primary source
    FLYBASE:FBgn0013432
    Locus tag
    Dmel_CG3717
    See related
    AllianceGenome:FB:FBgn0013432
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE57896; Bcn92; CG3717; Dmel\CG3717; EG:87B1.6; Isd11; NEST:bs15a04
    Summary
    Involved in iron-sulfur cluster assembly. Located in mitochondrion. Part of L-cysteine desulfurase complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 19. Orthologous to human LYRM4 (LYR motif containing 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    2D4-2D4; 1-0.6 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2148463..2149647, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2042496..2043680, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene polyhomeotic proximal Neighboring gene D-2-hydroxyglutaric acid dehydrogenase Neighboring gene Phosphogluconate dehydrogenase Neighboring gene wings apart-like Neighboring gene Cytochrome P450 4d1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of the breakpoints of an inversion fixed between Drosophila melanogaster and D. subobscura. Cirera S, et al. Genetics, 1995 Jan. PMID 7705632, Free PMC Article
    2. orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control. Fernandez-Acosta M, et al. BMC Biol, 2022 Oct 21. PMID 36266680, Free PMC Article
    3. Linking global histone acetylation to the transcription enhancement of X-chromosomal genes in Drosophila males. Smith ER, et al. J Biol Chem, 2001 Aug 24. PMID 11445559
    4. Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Vernì F, et al. Genetics, 2000 Apr. PMID 10747063, Free PMC Article
    5. Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. Feng S, et al. EMBO Rep, 2011 Feb. PMID 21164514, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of L-cysteine desulfurase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of L-cysteine desulfurase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of mitochondrial iron-sulfur cluster assembly complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bcn92
    Names
    CG3717-PA
    bcn92-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2148463..2149647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057711.3 → NP_477059.2  bcn92 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477059.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46098, Q9U5X3
      UniProtKB/TrEMBL
      A0A0F6QCW0
      Related
      FBpp0070415
      Conserved Domains (1) summary
      pfam13232
      Location:5 → 65
      Complex1_LYR_1; Complex1_LYR-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46098.1 O46098

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