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    Ring1 ring finger protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309626, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ring1provided by RGD
    Official Full Name
    ring finger protein 1provided by RGD
    Primary source
    RGD:3576
    See related
    Ensembl:ENSRNOG00000000467 AllianceGenome:RGD:3576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ring1A
    Summary
    Predicted to enable chromatin binding activity; ubiquitin protein ligase activity; and ubiquitin-protein transferase activator activity. Predicted to be involved in histone H2A monoubiquitination and negative regulation of transcription, DNA-templated. Predicted to act upstream of or within anterior/posterior pattern specification; camera-type eye morphogenesis; and histone ubiquitination. Predicted to be located in cytosol; nuclear body; and sex chromatin. Predicted to be part of PRC1 complex. Orthologous to human RING1 (ring finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 87.7), Kidney (RPKM 76.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4832013..4835516)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4830120..4833623)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3812287..3815834, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 8 Neighboring gene microRNA 219a-1 Neighboring gene uncharacterized LOC120098897 Neighboring gene RT1 class I, locus A3 Neighboring gene Sacm2l-ps2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal Patterns of RING1 Expression after Rat Spinal Cord Injury. Liu H, et al. Neurochem Res, 2017 Apr. PMID 28032293
    2. Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice. del Mar Lorente M, et al. Development, 2000 Dec. PMID 11060235
    3. Pax6 regulates boundary-cell specification in the rat hindbrain. Takahashi M, et al. Mech Dev, 2011 May-Jun. PMID 21501682
    4. Physical mapping and evolution of the centromeric class I gene-containing region of the rat MHC. Walter L, et al. Immunogenetics, 2000 Aug. PMID 10970097
    5. Physical mapping of the Ring1, Ring2, Ke6, Ke4, Rxrb, Col11a2, and RT1.Hb genes in the rat major histocompatibility complex. Walter L, et al. Immunogenetics, 1996. PMID 8662089

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RING1 protein levels were increased at day 3 after spinal cord injury and then decreased gradually.
      Title: Spatiotemporal Patterns of RING1 Expression after Rat Spinal Cord Injury.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112563

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in camera-type eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within_positive_effect chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of PRC1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PRC1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of PcG protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PcG protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of sex chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sex chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RING1
    Names
    RING-type E3 ubiquitin transferase RING1
    polycomb complex protein RING1
    NP_997714.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212549.2 → NP_997714.2  E3 ubiquitin-protein ligase RING1

      See identical proteins and their annotated locations for NP_997714.2

      Status: VALIDATED

      Source sequence(s)
      BC098635, JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q4KMC1, Q63510, Q6MGB6
      UniProtKB/TrEMBL
      A0A0G2K5V5, A6JJG6
      Related
      ENSRNOP00000000543.4, ENSRNOT00000000543.5
      Conserved Domains (2) summary
      cd16739
      Location:47 → 90
      RING-HC_RING1; RING finger, HC subclass, found in really interesting new gene 1 protein (RING1) and similar proteins
      cd17166
      Location:261 → 400
      RAWUL_RING1; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 1 protein (RING1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4832013..4835516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6MGB6.2 GenPept UniProtKB/Swiss-Prot:Q6MGB6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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