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    Vapa vesicle-associated membrane protein, associated protein A [ Mus musculus (house mouse) ]

    Gene ID: 30960, updated on 6-Oct-2024

    Summary

    Official Symbol
    Vapaprovided by MGI
    Official Full Name
    vesicle-associated membrane protein, associated protein Aprovided by MGI
    Primary source
    MGI:MGI:1353561
    See related
    Ensembl:ENSMUSG00000024091 AllianceGenome:MGI:1353561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    33kDa; VAP-A; VAP33; VAMP-A; VAP-33
    Summary
    Predicted to enable several functions, including FFAT motif binding activity; identical protein binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including COPII-coated vesicle budding; modulation by host of viral genome replication; and protein localization to endoplasmic reticulum. Located in endoplasmic reticulum and microtubule cytoskeleton. Orthologous to human VAPA (VAMP associated protein A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 108.3), adrenal adult (RPKM 93.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Vapa in Genome Data Viewer
    Location:
    17 E1.1; 17 34.9 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (65887048..65925441, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65580053..65616462, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35400 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene thioredoxin domain containing 2 (spermatozoa) Neighboring gene predicted gene, 35477 Neighboring gene STARR-seq mESC enhancer starr_43016 Neighboring gene RAB31, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_43017 Neighboring gene STARR-seq mESC enhancer starr_43022

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FFAT motif binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables FFAT motif binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle budding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in COPII-coated vesicle budding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ceramide transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum-plasma membrane tethering IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoplasmic reticulum-plasma membrane tethering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation by host of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation by host of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation by host of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation by host of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sphingomyelin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral release from host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral release from host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    vesicle-associated membrane protein-associated protein A
    Names
    33 kDa VAMP-associated protein
    VAMP-associated protein A
    synaptobrevin-associated protein of 33kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355402.1NP_001342331.1  vesicle-associated membrane protein-associated protein A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166058, CT030729
      UniProtKB/TrEMBL
      A0A3B2W837
      Related
      ENSMUSP00000156845.2, ENSMUST00000232686.2
      Conserved Domains (1) summary
      pfam00635
      Location:14118
      Motile_Sperm; MSP (Major sperm protein) domain
    2. NM_013933.3NP_038961.2  vesicle-associated membrane protein-associated protein A isoform 2

      See identical proteins and their annotated locations for NP_038961.2

      Status: VALIDATED

      Source sequence(s)
      AK167381, BM899396
      Consensus CDS
      CCDS37677.1
      UniProtKB/Swiss-Prot
      Q3TJM1, Q9QY77, Q9WV55
      Related
      ENSMUSP00000024897.9, ENSMUST00000024897.10
      Conserved Domains (1) summary
      pfam00635
      Location:14118
      Motile_Sperm; MSP (Major sperm protein) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      65887048..65925441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160637.1XP_036016530.1  vesicle-associated membrane protein-associated protein A isoform X2

      Conserved Domains (1) summary
      pfam00635
      Location:14118
      Motile_Sperm; MSP (Major sperm protein) domain
    2. XM_017317500.3XP_017172989.1  vesicle-associated membrane protein-associated protein A isoform X1

      UniProtKB/TrEMBL
      A0A3B2W837
      Conserved Domains (1) summary
      pfam00635
      Location:14118
      Motile_Sperm; MSP (Major sperm protein) domain