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    Pttg1 pituitary tumor-transforming gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 30939, updated on 10-Aug-2021

    Summary

    Official Symbol
    Pttg1provided by MGI
    Official Full Name
    pituitary tumor-transforming gene 1provided by MGI
    Primary source
    MGI:MGI:1353578
    See related
    Ensembl:ENSMUSG00000020415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTT; sec; Pttg; Pttg3; C87862; AW555095
    Expression
    Ubiquitous expression in bladder adult (RPKM 18.7), testis adult (RPKM 15.6) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pttg1 in Genome Data Viewer
    Location:
    11; 11 B1.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (43311071..43318290, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43420244..43427463, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (43233750..43239750, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 146 Neighboring gene predicted gene 5782 Neighboring gene SLU7 splicing factor homolog (S. cerevisiae) Neighboring gene predicted gene 12151

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    securin
    Names
    pituitary tumor-transforming 1
    pituitary tumor-transforming gene 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131054.2NP_001124526.1  securin isoform 1

      See identical proteins and their annotated locations for NP_001124526.1

      Status: VALIDATED

      Source sequence(s)
      AK002473, AL670472, CN837307, DV657646
      Consensus CDS
      CCDS48771.1
      UniProtKB/Swiss-Prot
      Q9CQJ7
      Related
      ENSMUSP00000020687.9, ENSMUST00000020687.15
      Conserved Domains (1) summary
      pfam04856
      Location:1188
      Securin; Securin sister-chromatid separation inhibitor
    2. NM_001362799.1NP_001349728.1  securin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670472, CK624973
      Consensus CDS
      CCDS48771.1
      Related
      ENSMUSP00000098894.5, ENSMUST00000101340.11
      Conserved Domains (1) summary
      pfam04856
      Location:1188
      Securin; Securin sister-chromatid separation inhibitor
    3. NM_013917.3NP_038945.2  securin isoform 2

      See identical proteins and their annotated locations for NP_038945.2

      Status: VALIDATED

      Source sequence(s)
      AF071209, AI790531, AK002473, AL670472, DV657646
      Consensus CDS
      CCDS24556.1
      UniProtKB/Swiss-Prot
      Q9CQJ7
      Related
      ENSMUSP00000112841.2, ENSMUST00000117446.8
      Conserved Domains (1) summary
      pfam04856
      Location:1173
      Securin; Securin sister-chromatid separation inhibitor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      43311071..43318290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246068.1XP_030101928.1  securin isoform X1

      Conserved Domains (1) summary
      pfam04856
      Location:1188
      Securin; Securin sister-chromatid separation inhibitor
    2. XM_006533516.5XP_006533579.1  securin isoform X1

      See identical proteins and their annotated locations for XP_006533579.1

      UniProtKB/Swiss-Prot
      Q9CQJ7
      Related
      ENSMUSP00000112834.2, ENSMUST00000118368.8
      Conserved Domains (1) summary
      pfam04856
      Location:1188
      Securin; Securin sister-chromatid separation inhibitor
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