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    Pttg1 pituitary tumor-transforming gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 30939, updated on 28-Aug-2018

    Summary

    Official Symbol
    Pttg1provided by MGI
    Official Full Name
    pituitary tumor-transforming gene 1provided by MGI
    Primary source
    MGI:MGI:1353578
    See related
    Ensembl:ENSMUSG00000020415 Vega:OTTMUSG00000005453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pttg; Pttg3; C87862; AW555095
    Expression
    Ubiquitous expression in bladder adult (RPKM 18.7), testis adult (RPKM 15.6) and 24 other tissues See more
    Orthologs

    Genomic context

    See Pttg1 in Genome Data Viewer
    Location:
    11; 11 B1.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (43420248..43426248, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (43233750..43239750, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene microRNA 146 Neighboring gene predicted gene 5782 Neighboring gene SLU7 splicing factor homolog (S. cerevisiae) Neighboring gene ribosomal protein 63, mitochondrial-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular process ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome organization IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    homologous chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    homologous chromosome segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitotic sister chromatid separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    securin
    Names
    pituitary tumor-transforming 1
    pituitary tumor-transforming gene 1 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131054.2NP_001124526.1  securin isoform 1

      See identical proteins and their annotated locations for NP_001124526.1

      Status: VALIDATED

      Source sequence(s)
      AK002473, AL670472, CN837307, DV657646
      Consensus CDS
      CCDS48771.1
      UniProtKB/Swiss-Prot
      Q9CQJ7
      Related
      ENSMUSP00000020687.8, OTTMUSP00000005608, ENSMUST00000020687.14
      Conserved Domains (1) summary
      pfam04856
      Location:1188
      Securin; Securin sister-chromatid separation inhibitor
    2. NM_001362799.1NP_001349728.1  securin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670472, CK624973
      Conserved Domains (1) summary
      pfam04856
      Location:1188
      Securin; Securin sister-chromatid separation inhibitor
    3. NM_013917.3NP_038945.2  securin isoform 2

      See identical proteins and their annotated locations for NP_038945.2

      Status: VALIDATED

      Source sequence(s)
      AF071209, AI790531, AK002473, AL670472, DV657646
      Consensus CDS
      CCDS24556.1
      UniProtKB/Swiss-Prot
      Q9CQJ7
      Related
      ENSMUSP00000112841.1, OTTMUSP00000040329, ENSMUST00000117446.7
      Conserved Domains (1) summary
      pfam04856
      Location:1173
      Securin; Securin sister-chromatid separation inhibitor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      43420248..43426248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533516.3XP_006533579.1  securin isoform X1

      See identical proteins and their annotated locations for XP_006533579.1

      UniProtKB/Swiss-Prot
      Q9CQJ7
      Related
      ENSMUSP00000112834.1, OTTMUSP00000040326, ENSMUST00000118368.7, OTTMUST00000076561
      Conserved Domains (1) summary
      pfam04856
      Location:1188
      Securin; Securin sister-chromatid separation inhibitor
    2. XM_006533515.3XP_006533578.1  securin isoform X1

      UniProtKB/Swiss-Prot
      Q9CQJ7
      Related
      ENSMUSP00000098894.4, OTTMUSP00000040327, ENSMUST00000101340.10, OTTMUST00000076562
      Conserved Domains (1) summary
      pfam04856
      Location:1188
      Securin; Securin sister-chromatid separation inhibitor
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