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    Glrx3 glutaredoxin 3 [ Mus musculus (house mouse) ]

    Gene ID: 30926, updated on 18-Sep-2024

    Summary

    Official Symbol
    Glrx3provided by MGI
    Official Full Name
    glutaredoxin 3provided by MGI
    Primary source
    MGI:MGI:1353653
    See related
    Ensembl:ENSMUSG00000031068 AllianceGenome:MGI:1353653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PICOT; Txnl2
    Summary
    Predicted to enable identical protein binding activity and protein kinase C binding activity. Involved in negative regulation of cardiac muscle hypertrophy and regulation of the force of heart contraction. Located in Z disc. Is expressed in several structures, including brain; egg cylinder; genitourinary system; gut; and white fat. Orthologous to human GLRX3 (glutaredoxin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 37.8), CNS E11.5 (RPKM 24.0) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Glrx3 in Genome Data Viewer
    Location:
    7 F4; 7 82.32 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (137039302..137071360)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (137437573..137469631)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430038I01 gene Neighboring gene STARR-positive B cell enhancer ABC_E2852 Neighboring gene STARR-seq mESC enhancer starr_20385 Neighboring gene nucleolin pseudogene Neighboring gene STARR-seq mESC enhancer starr_20386 Neighboring gene STARR-seq mESC enhancer starr_20387 Neighboring gene STARR-seq mESC enhancer starr_20388 Neighboring gene STARR-seq mESC enhancer starr_20391 Neighboring gene STARR-positive B cell enhancer ABC_E6613 Neighboring gene RIKEN cDNA 4930570E01 gene Neighboring gene STARR-seq mESC enhancer starr_20392 Neighboring gene STARR-seq mESC enhancer starr_20393 Neighboring gene predicted gene, 51411 Neighboring gene STARR-seq mESC enhancer starr_20395 Neighboring gene STARR-seq mESC enhancer starr_20396 Neighboring gene STARR-seq mESC enhancer starr_20397 Neighboring gene STARR-seq mESC enhancer starr_20398 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in [2Fe-2S] cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in [2Fe-2S] cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein maturation by iron-sulfur cluster transfer ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein maturation by iron-sulfur cluster transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of the force of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    part_of iron-sulfur cluster assembly complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    glutaredoxin-3
    Names
    PKC-interacting cousin of thioredoxin
    PKC-theta-interacting protein
    PKCq-interacting protein
    thioredoxin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348093.1NP_001335022.1  glutaredoxin-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' region and a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC131791
      Conserved Domains (1) summary
      cd03028
      Location:93181
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
    2. NM_023140.5NP_075629.2  glutaredoxin-3 isoform 1

      See identical proteins and their annotated locations for NP_075629.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC131791, AK017371, AK152446, BY771451
      Consensus CDS
      CCDS21948.1
      UniProtKB/Swiss-Prot
      Q5I0V8, Q9CQM9, Q9JLZ2
      UniProtKB/TrEMBL
      A0A1B0GS58
      Related
      ENSMUSP00000066621.7, ENSMUST00000064404.8
      Conserved Domains (2) summary
      cd02984
      Location:20115
      TRX_PICOT; TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily; PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT contains an ...
      cd03028
      Location:139227
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      137039302..137071360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)