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    Glrx3 glutaredoxin 3 [ Mus musculus (house mouse) ]

    Gene ID: 30926, updated on 31-Jan-2019

    Summary

    Official Symbol
    Glrx3provided by MGI
    Official Full Name
    glutaredoxin 3provided by MGI
    Primary source
    MGI:MGI:1353653
    See related
    Ensembl:ENSMUSG00000031068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PICOT; Txnl2
    Expression
    Ubiquitous expression in testis adult (RPKM 37.8), CNS E11.5 (RPKM 24.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See Glrx3 in Genome Data Viewer
    Location:
    7; 7 F4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (137436201..137468594)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (144629331..144660277)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430038I01 gene Neighboring gene nucleolin pseudogene Neighboring gene predicted gene, 39110 Neighboring gene RIKEN cDNA 4930570E01 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein disulfide oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    [2Fe-2S] cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein maturation by iron-sulfur cluster transfer ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of the force of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutaredoxin-3
    Names
    PKC-interacting cousin of thioredoxin
    PKC-theta-interacting protein
    PKCq-interacting protein
    thioredoxin-like protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348093.1NP_001335022.1  glutaredoxin-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' region and a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC131791
      Conserved Domains (1) summary
      cd03028
      Location:93181
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
    2. NM_023140.5NP_075629.2  glutaredoxin-3 isoform 1

      See identical proteins and their annotated locations for NP_075629.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC131791, AK017371, AK152446, BY771451
      Consensus CDS
      CCDS21948.1
      UniProtKB/Swiss-Prot
      Q9CQM9
      Related
      ENSMUSP00000066621.6, ENSMUST00000064404.7
      Conserved Domains (2) summary
      cd02984
      Location:20115
      TRX_PICOT; TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily; PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT contains an ...
      cd03028
      Location:139227
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      137436201..137468594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507916.3XP_006507979.1  glutaredoxin-3 isoform X1

      See identical proteins and their annotated locations for XP_006507979.1

      Conserved Domains (1) summary
      cd03028
      Location:93181
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...

    RNA

    1. XR_001785568.1 RNA Sequence

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