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    Gnl3 guanine nucleotide binding protein-like 3 (nucleolar) [ Mus musculus (house mouse) ]

    Gene ID: 30877, updated on 31-Jan-2019

    Summary

    Official Symbol
    Gnl3provided by MGI
    Official Full Name
    guanine nucleotide binding protein-like 3 (nucleolar)provided by MGI
    Primary source
    MGI:MGI:1353651
    See related
    Ensembl:ENSMUSG00000042354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ns
    Expression
    Broad expression in liver E14 (RPKM 33.9), liver E14.5 (RPKM 25.2) and 22 other tissues See more
    Orthologs

    Genomic context

    See Gnl3 in Genome Data Viewer
    Location:
    14 B; 14 19.09 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (31012433..31019131, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (31825619..31832275, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 4 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1 homolog (S. cerevisiae) Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene small nucleolar RNA, C/D box 19 Neighboring gene polybromo 1 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene small integral membrane protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC46970

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pri-miRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    stem cell division ISO
    Inferred from Sequence Orthology
    more info
     
    stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein-like 3
    Names
    nucleolar GTP-binding protein 3
    nucleostemin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153547.6NP_705775.2  guanine nucleotide-binding protein-like 3

      See identical proteins and their annotated locations for NP_705775.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
      Source sequence(s)
      AA041888, AK077523, CJ071960, CJ089318
      Consensus CDS
      CCDS26905.1
      UniProtKB/Swiss-Prot
      Q8CI11
      Related
      ENSMUSP00000047119.6, ENSMUST00000037739.7
      Conserved Domains (3) summary
      cd04178
      Location:140302
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      TIGR03596
      Location:130395
      GTPase_YlqF; ribosome biogenesis GTP-binding protein YlqF
      pfam08701
      Location:1693
      GN3L_Grn1; GNL3L/Grn1 putative GTPase

    RNA

    1. NR_104298.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate splice sites at internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AA041888, AK077523, AK167094, CJ071960, CJ089318
      Related
      ENSMUST00000226740.1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      31012433..31019131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178846.2: Suppressed sequence

      Description
      NM_178846.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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