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    Kdm2b lysine (K)-specific demethylase 2B [ Mus musculus (house mouse) ]

    Gene ID: 30841, updated on 5-Sep-2021

    Summary

    Official Symbol
    Kdm2bprovided by MGI
    Official Full Name
    lysine (K)-specific demethylase 2Bprovided by MGI
    Primary source
    MGI:MGI:1354737
    See related
    Ensembl:ENSMUSG00000029475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cxxc2; Fbl10; Fbxl1; PCCX2; Fbxl10; Jhdm1b
    Summary
    The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 10.9), whole brain E14.5 (RPKM 10.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kdm2b in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123008727..123127333, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122870664..122989270, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (123320677..123439101, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33044 Neighboring gene ring finger protein 34 Neighboring gene predicted gene, 33118 Neighboring gene RIKEN cDNA A930024E05 gene Neighboring gene predicted gene 2479

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA3014, E430001G17

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3-di/monomethyl-lysine-36 demethylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3-methyl-lysine-36 demethylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone demethylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables unmethylated CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fourth ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H2A monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within histone H3-K36 demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone H3-K36 demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in initiation of neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lateral ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in midbrain-hindbrain boundary morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of stem cell population maintenance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in third ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lysine-specific demethylase 2B
    Names
    F-box and leucine-rich repeat protein 10
    F-box protein FBL10
    F-box protein containing leucine repeats 10
    F-box/LRR-repeat protein 10
    [Histone-H3]-lysine-36 demethylase 1B
    jmjC domain-containing histone demethylation protein 1B
    NP_001003953.1
    NP_001365792.1
    NP_001365793.1
    NP_001365794.1
    NP_038938.1
    XP_006530439.1
    XP_011246510.1
    XP_011246511.1
    XP_011246512.1
    XP_011246513.1
    XP_011246514.1
    XP_011246515.1
    XP_011246516.1
    XP_011246517.1
    XP_011246518.1
    XP_036021058.1
    XP_036021059.1
    XP_036021060.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003953.2NP_001003953.1  lysine-specific demethylase 2B isoform 1

      See identical proteins and their annotated locations for NP_001003953.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK136625, BC065090
      Consensus CDS
      CCDS39259.1
      UniProtKB/Swiss-Prot
      Q6P1G2
      Related
      ENSMUSP00000038229.10, ENSMUST00000046073.16
      Conserved Domains (7) summary
      cd09293
      Location:10801280
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam02008
      Location:588624
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:10751099
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:634695
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:10411081
      F-box-like; F-box-like
      cl21464
      Location:198304
      cupin_like; Conserved domain found in cupin and related proteins
    2. NM_001378863.1NP_001365792.1  lysine-specific demethylase 2B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC121564
      Related
      ENSMUSP00000083376.5, ENSMUST00000086200.11
      Conserved Domains (10) summary
      PTZ00449
      Location:687986
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:10741274
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:145220
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:10691093
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:628689
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:582618
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:10351073
      F-box-like
      pfam17811
      Location:297332
      JHD; Jumonji helical domain
      cl40423
      Location:192298
      cupin_RmlC-like; RmlC-like cupin superfamily
      cl40435
      Location:474540
      CTD_KDM2A_2B-like; C-terminal domain found in lysine-specific demethylase KDM2A, KDM2B, and similar proteins
    3. NM_001378864.1NP_001365793.1  lysine-specific demethylase 2B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC121564
      Conserved Domains (6) summary
      PTZ00449
      Location:160462
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:561750
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:545569
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:101162
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:5591
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:511549
      F-box-like
    4. NM_001378865.1NP_001365794.1  lysine-specific demethylase 2B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC121564
      Conserved Domains (5) summary
      cd09293
      Location:520709
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:504528
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:101162
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:5591
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:470508
      F-box-like
    5. NM_013910.2NP_038938.1  lysine-specific demethylase 2B isoform 2

      See identical proteins and their annotated locations for NP_038938.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks exons in the 5' UTR and 5' coding region and uses an alternate 5' terminal exon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC057622, BC065090, BU841175
      Consensus CDS
      CCDS19657.1
      UniProtKB/Swiss-Prot
      Q6P1G2
      Related
      ENSMUSP00000031435.8, ENSMUST00000031435.14
      Conserved Domains (5) summary
      cd09293
      Location:558747
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:5591
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:542566
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:101162
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:508548
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      123008727..123127333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530376.4XP_006530439.1  lysine-specific demethylase 2B isoform X4

      Related
      ENSMUSP00000114052.3, ENSMUST00000118027.8
      Conserved Domains (9) summary
      cd09293
      Location:10421242
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:10371061
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:634695
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:588624
      zf-CXXC; CXXC zinc finger domain
      pfam10477
      Location:718922
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
      pfam12937
      Location:10031041
      F-box-like
      pfam17811
      Location:303338
      JHD; Jumonji helical domain
      cl21464
      Location:198297
      cupin_like; Conserved domain found in cupin and related proteins
    2. XM_011248210.3XP_011246512.1  lysine-specific demethylase 2B isoform X3

      Conserved Domains (9) summary
      cd09293
      Location:10451245
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:10401064
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:634695
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:588624
      zf-CXXC; CXXC zinc finger domain
      pfam10477
      Location:721925
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
      pfam12937
      Location:10061044
      F-box-like
      pfam17811
      Location:303338
      JHD; Jumonji helical domain
      cl21464
      Location:198297
      cupin_like; Conserved domain found in cupin and related proteins
    3. XM_011248208.3XP_011246510.1  lysine-specific demethylase 2B isoform X1

      Conserved Domains (9) summary
      PTZ00449
      Location:693995
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:10831283
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:10781102
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:634695
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:588624
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:10441082
      F-box-like
      pfam17811
      Location:303338
      JHD; Jumonji helical domain
      cl21464
      Location:198297
      cupin_like; Conserved domain found in cupin and related proteins
    4. XM_011248212.4XP_011246514.1  lysine-specific demethylase 2B isoform X5

      See identical proteins and their annotated locations for XP_011246514.1

      Related
      ENSMUSP00000114049.2, ENSMUST00000121739.8
      Conserved Domains (9) summary
      PTZ00449
      Location:638940
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:10281228
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:96171
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:10231047
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:579640
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:533569
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:9891027
      F-box-like
      pfam17811
      Location:248283
      JHD; Jumonji helical domain
      cl21464
      Location:143242
      cupin_like; Conserved domain found in cupin and related proteins
    5. XM_011248211.4XP_011246513.1  lysine-specific demethylase 2B isoform X5

      See identical proteins and their annotated locations for XP_011246513.1

      Conserved Domains (9) summary
      PTZ00449
      Location:638940
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:10281228
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:96171
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:10231047
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:579640
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:533569
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:9891027
      F-box-like
      pfam17811
      Location:248283
      JHD; Jumonji helical domain
      cl21464
      Location:143242
      cupin_like; Conserved domain found in cupin and related proteins
    6. XM_011248209.4XP_011246511.1  lysine-specific demethylase 2B isoform X2

      Conserved Domains (9) summary
      PTZ00449
      Location:687989
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:10771277
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:145220
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:10721096
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:628689
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:582618
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:10381076
      F-box-like
      pfam17811
      Location:297332
      JHD; Jumonji helical domain
      cl21464
      Location:192291
      cupin_like; Conserved domain found in cupin and related proteins
    7. XM_011248215.2XP_011246517.1  lysine-specific demethylase 2B isoform X8

      Conserved Domains (9) summary
      PTZ00449
      Location:607909
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:9971197
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:65140
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:9921016
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:548609
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:502538
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:958996
      F-box-like
      pfam17811
      Location:217252
      JHD; Jumonji helical domain
      cl21464
      Location:112211
      cupin_like; Conserved domain found in cupin and related proteins
    8. XM_036165165.1XP_036021058.1  lysine-specific demethylase 2B isoform X7

      Conserved Domains (9) summary
      PTZ00449
      Location:493792
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:8801080
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:875899
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:434495
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:388424
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:841879
      F-box-like
      pfam17811
      Location:103138
      JHD; Jumonji helical domain
      cd21785
      Location:280346
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
      cl40423
      Location:1104
      cupin_RmlC-like; RmlC-like cupin superfamily
    9. XM_011248214.3XP_011246516.1  lysine-specific demethylase 2B isoform X6

      See identical proteins and their annotated locations for XP_011246516.1

      Conserved Domains (8) summary
      PTZ00449
      Location:493795
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:8831083
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:878902
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:434495
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:388424
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:844882
      F-box-like
      pfam17811
      Location:103138
      JHD; Jumonji helical domain
      cl21464
      Location:197
      cupin_like; Conserved domain found in cupin and related proteins
    10. XM_011248213.4XP_011246515.1  lysine-specific demethylase 2B isoform X6

      See identical proteins and their annotated locations for XP_011246515.1

      Conserved Domains (8) summary
      PTZ00449
      Location:493795
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:8831083
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:878902
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:434495
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:388424
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:844882
      F-box-like
      pfam17811
      Location:103138
      JHD; Jumonji helical domain
      cl21464
      Location:197
      cupin_like; Conserved domain found in cupin and related proteins
    11. XM_011248216.3XP_011246518.1  lysine-specific demethylase 2B isoform X6

      See identical proteins and their annotated locations for XP_011246518.1

      Conserved Domains (8) summary
      PTZ00449
      Location:493795
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:8831083
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:878902
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:434495
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:388424
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:844882
      F-box-like
      pfam17811
      Location:103138
      JHD; Jumonji helical domain
      cl21464
      Location:197
      cupin_like; Conserved domain found in cupin and related proteins
    12. XM_036165167.1XP_036021060.1  lysine-specific demethylase 2B isoform X10

      Conserved Domains (7) summary
      PTZ00449
      Location:363662
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:750950
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:745769
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:304365
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:258294
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:711749
      F-box-like
      cd21785
      Location:150216
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
    13. XM_036165166.1XP_036021059.1  lysine-specific demethylase 2B isoform X9

      Conserved Domains (7) summary
      PTZ00449
      Location:363665
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:753953
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:748772
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:304365
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:258294
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:714752
      F-box-like
      cd21785
      Location:150216
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005866.1: Suppressed sequence

      Description
      NM_001005866.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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