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    ANXA4 annexin A4 [ Homo sapiens (human) ]

    Gene ID: 307, updated on 2-Nov-2024

    Summary

    Official Symbol
    ANXA4provided by HGNC
    Official Full Name
    annexin A4provided by HGNC
    Primary source
    HGNC:HGNC:542
    See related
    Ensembl:ENSG00000196975 MIM:106491; AllianceGenome:HGNC:542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANX4; P32.5; PIG28; PP4-X; ZAP36; PAP-II; HEL-S-274
    Summary
    Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
    Expression
    Broad expression in gall bladder (RPKM 187.6), duodenum (RPKM 64.1) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ANXA4 in Genome Data Viewer
    Location:
    2p13.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (69643808..69827112)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (69656119..69839380)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (69870940..70054244)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene AP2 associated kinase 1 Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 1 pseudogene 1 Neighboring gene ribosomal protein L36a pseudogene 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15975 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:69872055-69872657 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15977 Neighboring gene SMARCA4 interacting SWI/SNF chromatin remodeling complex scaffold lncRNA Neighboring gene uncharacterized LOC124906021 Neighboring gene H3K27ac hESC enhancers GRCh37_chr2:70055828-70056749 and GRCh37_chr2:70056750-70057670 Neighboring gene germ cell-less 1, spermatogenesis associated Neighboring gene ribosomal protein L23a pseudogene 92 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70120713-70121648 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70121649-70122583 Neighboring gene small nuclear ribonucleoprotein U4/U6.U5 subunit 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of annexin A4 and V in umbilical cord blood mononuclear cells and T-cell lines but downregulates the expression of annexin A1 in umbilical cord blood mononuclear cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC75105, DKFZp686H02120

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NF-kappaB binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-dependent phospholipid binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipase inhibitor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in zymogen granule membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    annexin A4
    Names
    35-beta calcimedin
    annexin IV (placental anticoagulant protein II)
    annexin-4
    carbohydrate-binding protein p33/p41
    chromobindin-4
    endonexin I
    epididymis secretory protein Li 274
    lipocortin IV
    placental anticoagulant protein II
    proliferation-inducing gene 28
    proliferation-inducing protein 28
    protein II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001153.5NP_001144.1  annexin A4 isoform a

      See identical proteins and their annotated locations for NP_001144.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC019206, AK058017, BC000182, D78152, DB562261
      Consensus CDS
      CCDS1894.1
      UniProtKB/TrEMBL
      V9HW59
      Related
      ENSP00000377833.4, ENST00000394295.6
      Conserved Domains (1) summary
      pfam00191
      Location:251316
      Annexin
    2. NM_001320698.2NP_001307627.1  annexin A4 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC019206, AC092431, AK058017, BC000182, D78152, DB562261, DN994496
      Consensus CDS
      CCDS1894.1
      UniProtKB/TrEMBL
      V9HW59
      Conserved Domains (1) summary
      pfam00191
      Location:251316
      Annexin
    3. NM_001320700.2NP_001307629.1  annexin A4 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC019206, AK058017, BC063672, D78152, DB562261
      Consensus CDS
      CCDS82459.1
      UniProtKB/TrEMBL
      B4DDZ4, Q6P452
      Related
      ENSP00000386756.1, ENST00000409920.5
      Conserved Domains (2) summary
      smart00335
      Location:83135
      ANX; Annexin repeats
      pfam00191
      Location:229294
      Annexin; Annexin
    4. NM_001320702.2NP_001307631.1  annexin A4 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC019206, AK058017, AK293177, D78152, DB562261
      UniProtKB/Swiss-Prot
      P09525
      UniProtKB/TrEMBL
      Q6P452
      Conserved Domains (1) summary
      pfam00191
      Location:167232
      Annexin
    5. NM_001365496.2NP_001352425.1  annexin A4 isoform a

      Status: REVIEWED

      Source sequence(s)
      AA237007, AC019206, BX110594, CN287596, CU446263, DB562261, DC380425
      Consensus CDS
      CCDS1894.1
      UniProtKB/TrEMBL
      V9HW59
      Conserved Domains (1) summary
      pfam00191
      Location:251316
      Annexin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      69643808..69827112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444083.1XP_047300039.1  annexin A4 isoform X1

    2. XM_017003943.2XP_016859432.1  annexin A4 isoform X1

      UniProtKB/TrEMBL
      V9HW59
      Conserved Domains (1) summary
      pfam00191
      Location:251316
      Annexin
    3. XM_024452835.2XP_024308603.1  annexin A4 isoform X1

      UniProtKB/TrEMBL
      V9HW59
      Conserved Domains (1) summary
      pfam00191
      Location:251316
      Annexin
    4. XM_047444082.1XP_047300038.1  annexin A4 isoform X1

    5. XM_047444081.1XP_047300037.1  annexin A4 isoform X1

    6. XM_047444080.1XP_047300036.1  annexin A4 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      69656119..69839380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341638.1XP_054197613.1  annexin A4 isoform X1

    2. XM_054341636.1XP_054197611.1  annexin A4 isoform X1

    3. XM_054341637.1XP_054197612.1  annexin A4 isoform X1

    4. XM_054341635.1XP_054197610.1  annexin A4 isoform X1

    5. XM_054341634.1XP_054197609.1  annexin A4 isoform X1

    6. XM_054341633.1XP_054197608.1  annexin A4 isoform X1