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    HDC histidine decarboxylase [ Homo sapiens (human) ]

    Gene ID: 3067, updated on 11-Apr-2024

    Summary

    Official Symbol
    HDCprovided by HGNC
    Official Full Name
    histidine decarboxylaseprovided by HGNC
    Primary source
    HGNC:HGNC:4855
    See related
    Ensembl:ENSG00000140287 MIM:142704; AllianceGenome:HGNC:4855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]
    Expression
    Broad expression in gall bladder (RPKM 9.0), stomach (RPKM 6.4) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HDC in Genome Data Viewer
    Location:
    15q21.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (50241947..50265726, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (48050179..48073964, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (50534144..50557923, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8B4 (putative) Neighboring gene RNA, 5S ribosomal pseudogene 394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9389 Neighboring gene Sharpr-MPRA regulatory region 771 Neighboring gene Sharpr-MPRA regulatory region 7155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9390 Neighboring gene NANOG hESC enhancer GRCh37_chr15:50408634-50409147 Neighboring gene ATP8B4 intron CAGE-defined high expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:50502954-50503533 Neighboring gene solute carrier family 27 member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:50544247-50544748 Neighboring gene RNA, 7SL, cytoplasmic 494, pseudogene Neighboring gene GA binding protein transcription factor subunit beta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6426 Neighboring gene GABPB1 intronic transcript Neighboring gene GABPB1 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 94, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC163399

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histidine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histidine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in catecholamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in histamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histidine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in histidine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histidine metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    histidine decarboxylase
    NP_001293075.1
    NP_002103.2
    XP_016877583.1
    XP_016877584.1
    XP_016877586.1
    XP_016877587.1
    XP_016877588.1
    XP_054233733.1
    XP_054233734.1
    XP_054233735.1
    XP_054233736.1
    XP_054233737.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027487.1 RefSeqGene

      Range
      5240..29019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306146.2NP_001293075.1  histidine decarboxylase isoform 2

      See identical proteins and their annotated locations for NP_001293075.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC022087, AK027221, BC144173
      Consensus CDS
      CCDS76754.1
      UniProtKB/Swiss-Prot
      P19113
      Related
      ENSP00000440252.1, ENST00000543581.5
      Conserved Domains (1) summary
      pfam00282
      Location:36381
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    2. NM_002112.4NP_002103.2  histidine decarboxylase isoform 1

      See identical proteins and their annotated locations for NP_002103.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL041199, M60445
      Consensus CDS
      CCDS10134.1
      UniProtKB/Swiss-Prot
      A1L4G0, B7ZM01, P19113
      Related
      ENSP00000267845.3, ENST00000267845.8
      Conserved Domains (1) summary
      pfam00282
      Location:36414
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      50241947..50265726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022097.2XP_016877586.1  histidine decarboxylase isoform X3

    2. XM_017022095.2XP_016877584.1  histidine decarboxylase isoform X2

    3. XM_017022094.2XP_016877583.1  histidine decarboxylase isoform X1

    4. XM_017022098.2XP_016877587.1  histidine decarboxylase isoform X4

    5. XM_017022099.2XP_016877588.1  histidine decarboxylase isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      48050179..48073964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377760.1XP_054233735.1  histidine decarboxylase isoform X3

    2. XM_054377759.1XP_054233734.1  histidine decarboxylase isoform X2

    3. XM_054377758.1XP_054233733.1  histidine decarboxylase isoform X1

    4. XM_054377761.1XP_054233736.1  histidine decarboxylase isoform X4

    5. XM_054377762.1XP_054233737.1  histidine decarboxylase isoform X5