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    ANXA1 annexin A1 [ Homo sapiens (human) ]

    Gene ID: 301, updated on 20-Sep-2020

    Summary

    Official Symbol
    ANXA1provided by HGNC
    Official Full Name
    annexin A1provided by HGNC
    Primary source
    HGNC:HGNC:533
    See related
    Ensembl:ENSG00000135046 MIM:151690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANX1; LPC1
    Summary
    This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in esophagus (RPKM 2850.3), bone marrow (RPKM 574.5) and 4 other tissues See more
    Orthologs

    Genomic context

    See ANXA1 in Genome Data Viewer
    Location:
    9q21.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (73151865..73170393)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (75766721..75785309)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr9.871 Neighboring gene CRISPRi-validated cis-regulatory element chr9.872 Neighboring gene uncharacterized LOC105376082 Neighboring gene uncharacterized LOC101927281

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of annexin A4 and V in umbilical cord blood mononuclear cells and T-cell lines but downregulates the expression of annexin A1 in umbilical cord blood mononuclear cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ18726

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA/DNA annealing activity IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding involved in cell-cell adhesion HDA PubMed 
    calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    double-stranded DNA-dependent ATP-dependent DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase A2 inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phospholipase A2 inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin cytoskeleton reorganization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin cytoskeleton reorganization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    alpha-beta T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alpha-beta T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    arachidonic acid secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucocorticoid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to glucocorticoid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hydrogen peroxide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    endocrine pancreas development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT estrous cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    gliogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    granulocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    granulocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hepatocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    keratinocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myoblast migration involved in skeletal muscle regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of T-helper 2 cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of T-helper 2 cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-8 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neutrophil clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptide cross-linking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T-helper 1 cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of T-helper 1 cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration involved in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-2 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interleukin-2 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neutrophil apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of prostaglandin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of vesicle fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prolactin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    prostate gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of hormone secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of interleukin-1 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of interleukin-1 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of leukocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of leukocyte migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to X-ray IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to drug IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to estradiol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to interleukin-1 IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adherens junction HDA PubMed 
    apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen-containing extracellular matrix HDA PubMed 
    cornified envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space HDA PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extrinsic component of external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion HDA PubMed 
    lateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mast cell granule IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytic cup IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle HDA PubMed 

    General protein information

    Preferred Names
    annexin A1
    Names
    annexin I (lipocortin I)
    annexin-1
    calpactin II
    calpactin-2
    chromobindin-9
    epididymis secretory sperm binding protein
    phospholipase A2 inhibitory protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000700.3NP_000691.1  annexin A1

      See identical proteins and their annotated locations for NP_000691.1

      Status: REVIEWED

      Source sequence(s)
      AA039737, AL359997, X05908
      Consensus CDS
      CCDS6645.1
      UniProtKB/Swiss-Prot
      P04083
      UniProtKB/TrEMBL
      Q5TZZ9
      Related
      ENSP00000257497.6, ENST00000257497.11
      Conserved Domains (1) summary
      pfam00191
      Location:118183
      Annexin; Annexin

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      73151865..73170393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014657.1XP_016870146.1  annexin A1 isoform X1

      Conserved Domains (1) summary
      pfam00191
      Location:129194
      Annexin; Annexin
    2. XM_011518609.1XP_011516911.1  annexin A1 isoform X2

      See identical proteins and their annotated locations for XP_011516911.1

      UniProtKB/Swiss-Prot
      P04083
      UniProtKB/TrEMBL
      Q5TZZ9
      Conserved Domains (1) summary
      pfam00191
      Location:118183
      Annexin; Annexin
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