U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    H1-4 H1.4 linker histone, cluster member [ Homo sapiens (human) ]

    Gene ID: 3008, updated on 17-Jun-2024

    Summary

    Official Symbol
    H1-4provided by HGNC
    Official Full Name
    H1.4 linker histone, cluster memberprovided by HGNC
    Primary source
    HGNC:HGNC:4718
    See related
    Ensembl:ENSG00000168298 MIM:142220; AllianceGenome:HGNC:4718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H1E; H1.4; H1F4; RMNS; H1s-4; HIST1H1E; dJ221C16.5
    Summary
    Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See H1-4 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26156329..26157115)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26024465..26025251)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26156557..26157343)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H2B clustered histone 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26121574-26122260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26122261-26122945 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:26123079-26124278 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:26124310-26125509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24192 Neighboring gene H2A clustered histone 6 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26156285-26157036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17001 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26157790-26158541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24195 Neighboring gene Sharpr-MPRA regulatory region 13869 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26160799-26161550 Neighboring gene H2BC6 antisense RNA 1 Neighboring gene H2B clustered histone 5 Neighboring gene LARP1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26172075-26172967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24196 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26183023-26183752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24198 Neighboring gene H2B clustered histone 6

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Rahman syndrome
    MedGen: C4479637 OMIM: 617537 GeneReviews: HIST1H1E Syndrome
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2022-07-27)

    ClinGen Genome Curation Page
    Haploinsufficency

    No evidence available (Last evaluated 2022-07-27)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Overexpression of NPM1 enhances HIV-1 Tat-mediated transactivation by reducing the histone H1 occupancy on the chromatinized template of HIV-1 LTR PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC116819

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables chromatin DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of euchromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H1.4
    Names
    H1 histone family, member 4
    histone 1, H1e
    histone H1b
    histone H1s-4
    histone cluster 1 H1 family member e
    histone cluster 1, H1e

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005321.3NP_005312.1  histone H1.4

      See identical proteins and their annotated locations for NP_005312.1

      Status: REVIEWED

      Source sequence(s)
      AL353759
      Consensus CDS
      CCDS4586.1
      UniProtKB/Swiss-Prot
      P10412, Q4VB25
      UniProtKB/TrEMBL
      A3R0T8, Q4VB24
      Related
      ENSP00000307705.4, ENST00000304218.6
      Conserved Domains (1) summary
      cd00073
      Location:34114
      H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26156329..26157115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      26024465..26025251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)