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    H1-2 H1.2 linker histone, cluster member [ Homo sapiens (human) ]

    Gene ID: 3006, updated on 17-Jun-2024

    Summary

    Official Symbol
    H1-2provided by HGNC
    Official Full Name
    H1.2 linker histone, cluster memberprovided by HGNC
    Primary source
    HGNC:HGNC:4716
    See related
    Ensembl:ENSG00000187837 MIM:142710; AllianceGenome:HGNC:4716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H1C; H1.2; H1F2; H1s-1; HIST1H1C
    Summary
    Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
    Orthologs
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    Genomic context

    See H1-2 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26055740..26056470, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (25923905..25924635, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26055968..26056698, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24185 Neighboring gene H2A clustered histone 5, pseudogene Neighboring gene H3 clustered histone 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:26053365-26053538 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26053937-26054558 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26055179-26055800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17000 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26066841-26067340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:26075238-26075738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:26075739-26076239 Neighboring gene HFE antisense RNA 1 Neighboring gene homeostatic iron regulator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24188 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:26103833-26104523 Neighboring gene H4 clustered histone 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated histone cluster 1, H1c (HIST1H1C) protein is incorporated into HIV-1 Gag virus-like particles PubMed
    Tat tat Overexpression of NPM1 enhances HIV-1 Tat-mediated transactivation by reducing the histone H1 occupancy on the chromatinized template of HIV-1 LTR PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3992

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of euchromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H1.2
    Names
    H1 histone family, member 2
    histone 1, H1c
    histone H1c
    histone H1d
    histone H1s-1
    histone cluster 1 H1 family member c
    histone cluster 1, H1c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005319.4NP_005310.1  histone H1.2

      See identical proteins and their annotated locations for NP_005310.1

      Status: REVIEWED

      Source sequence(s)
      U91328
      Consensus CDS
      CCDS4577.1
      UniProtKB/Swiss-Prot
      A8K4I2, P16403
      Related
      ENSP00000339566.3, ENST00000343677.4
      Conserved Domains (1) summary
      pfam00538
      Location:38108
      Linker_histone; linker histone H1 and H5 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26055740..26056470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      25923905..25924635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)