Format

Send to:

Choose Destination
    • Showing Current items.

    Fbxw2 F-box and WD-40 domain protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 30050, updated on 3-Feb-2019

    Summary

    Official Symbol
    Fbxw2provided by MGI
    Official Full Name
    F-box and WD-40 domain protein 2provided by MGI
    Primary source
    MGI:MGI:1353435
    See related
    Ensembl:ENSMUSG00000035949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MD6; FBW2; Fwd2; 2700071L08Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 8.5), bladder adult (RPKM 8.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Fbxw2 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (34804364..34826274, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (34659884..34681755, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene heat shock protein 5 Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene predicted gene, 34653 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box/WD repeat-containing protein 2
    Names
    F-box and WD-40 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164768.1NP_001158240.1  F-box/WD repeat-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001158240.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR and encodes the same isoform 1, compared to variant 1.
      Source sequence(s)
      AF140683, AL929106, CB203503
      Consensus CDS
      CCDS15952.1
      UniProtKB/TrEMBL
      Q9QUH1
      Related
      ENSMUSP00000108701.1, ENSMUST00000113078.7
      Conserved Domains (3) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:151185
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:140447
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001164769.1NP_001158241.1  F-box/WD repeat-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001158241.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks the 3' exon, but has an alternate 3' sequence, compared to variant 1. The resulting isoform (2) is C-terminal truncated, compared to isoform 1.
      Source sequence(s)
      AK040764, AK078815
      Consensus CDS
      CCDS50574.1
      UniProtKB/TrEMBL
      Q8BS25
      Related
      ENSMUSP00000108698.1, ENSMUST00000113075.7
      Conserved Domains (4) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      COG2319
      Location:140359
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:151185
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:140354
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001164770.1NP_001158242.1  F-box/WD repeat-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001158242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal segment in the 5' region, resulting in a downstream in-frame AUG start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK078815, AL929106
      Consensus CDS
      CCDS50573.1
      UniProtKB/TrEMBL
      A2AUF9
      Related
      ENSMUSP00000088541.3, ENSMUST00000091020.9
      Conserved Domains (2) summary
      sd00039
      Location:2256
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:11318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_001164772.1NP_001158244.1  F-box/WD repeat-containing protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001158244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks several 3' exons, but has an alternate 3' sequence, compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK005103, AK078815, AK145405
      UniProtKB/TrEMBL
      Q9CPQ6
      Conserved Domains (4) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      COG2319
      Location:142236
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:151185
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:140232
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. NM_013890.4NP_038918.3  F-box/WD repeat-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_038918.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK033129, AK078815, AL929106
      Consensus CDS
      CCDS15952.1
      UniProtKB/TrEMBL
      Q8CCH8, Q9QUH1
      Related
      ENSMUSP00000108703.2, ENSMUST00000113080.8
      Conserved Domains (3) summary
      smart00256
      Location:6094
      FBOX; A Receptor for Ubiquitination Targets
      sd00039
      Location:151185
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:140447
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      34804364..34826274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498117.3XP_006498180.1  F-box/WD repeat-containing protein 2 isoform X1

      Conserved Domains (4) summary
      smart00256
      Location:97131
      FBOX; A Receptor for Ubiquitination Targets
      COG2319
      Location:177438
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:188222
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:177484
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006498118.3XP_006498181.1  F-box/WD repeat-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006498181.1

      UniProtKB/TrEMBL
      A2AUF9
      Conserved Domains (2) summary
      sd00039
      Location:2256
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:11318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Support Center