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    STRN3 striatin 3 [ Homo sapiens (human) ]

    Gene ID: 29966, updated on 7-Jul-2024

    Summary

    Official Symbol
    STRN3provided by HGNC
    Official Full Name
    striatin 3provided by HGNC
    Primary source
    HGNC:HGNC:15720
    See related
    Ensembl:ENSG00000196792 MIM:614766; AllianceGenome:HGNC:15720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SG2NA; S/G2NA; PPP2R6B
    Summary
    Enables armadillo repeat domain binding activity; protein phosphatase 2A binding activity; and small GTPase binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; nucleoplasm; and plasma membrane. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 11.4), fat (RPKM 8.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STRN3 in Genome Data Viewer
    Location:
    14q12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (30893804..31026379, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (25091284..25224212, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31363010..31495585, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5649 Neighboring gene uncharacterized LOC100506071 Neighboring gene cochlin Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 17 Neighboring gene intraflagellar transport 20 homolog (Chlamydomonas) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5650 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:31494803-31494984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8229 Neighboring gene microRNA 624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:31516497-31517022 Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5652 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:31591905-31592742 Neighboring gene HECT domain E3 ubiquitin protein ligase 1 Neighboring gene ribosomal protein L21 pseudogene 5 Neighboring gene RNA, U6 small nuclear 541, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables armadillo repeat domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables armadillo repeat domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase 2A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase 2A binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hippo signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of intracellular estrogen receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to estradiol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    striatin-3
    Names
    cell cycle S/G2 nuclear autoantigen
    cell cycle autoantigen SG2NA
    nuclear autoantigen
    protein phosphatase 2 regulatory subunit B'''beta
    s/G2 antigen
    striatin, calmodulin binding protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083893.2NP_001077362.1  striatin-3 isoform 1

      See identical proteins and their annotated locations for NP_001077362.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), also known as the beta isoform.
      Source sequence(s)
      AA572712, AF243424, AL049830, BC132673, DA854600
      Consensus CDS
      CCDS41938.1
      UniProtKB/Swiss-Prot
      A2RTX7, A6NHZ7, Q13033, Q9NRA5
      UniProtKB/TrEMBL
      A0AV58
      Related
      ENSP00000350071.5, ENST00000357479.10
      Conserved Domains (4) summary
      COG2319
      Location:473790
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:475796
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08232
      Location:64190
      Striatin; Striatin family
      sd00039
      Location:485531
      7WD40; WD40 repeat [structural motif]
    2. NM_014574.4NP_055389.3  striatin-3 isoform 2

      See identical proteins and their annotated locations for NP_055389.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 2, also known as the alpha isoform), compared to isoform 1.
      Source sequence(s)
      AA572712, AL049830, BC132673, DA854600
      Consensus CDS
      CCDS9641.1
      UniProtKB/TrEMBL
      A0AV58
      Related
      ENSP00000347909.5, ENST00000355683.9
      Conserved Domains (3) summary
      cd00200
      Location:391712
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:401447
      7WD40; WD40 repeat [structural motif]
      pfam08232
      Location:65190
      Striatin; Striatin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      30893804..31026379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005267569.5XP_005267626.1  striatin-3 isoform X2

      UniProtKB/TrEMBL
      A0AV58
      Conserved Domains (4) summary
      COG2319
      Location:436753
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:438759
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08232
      Location:64190
      Striatin; Striatin family
      sd00039
      Location:448494
      7WD40; WD40 repeat [structural motif]
    2. XM_005267570.5XP_005267627.1  striatin-3 isoform X3

      UniProtKB/TrEMBL
      A0AV58
      Conserved Domains (4) summary
      COG2319
      Location:426743
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:428749
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08232
      Location:64190
      Striatin; Striatin family
      sd00039
      Location:438484
      7WD40; WD40 repeat [structural motif]
    3. XM_047431321.1XP_047287277.1  striatin-3 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      25091284..25224212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375934.1XP_054231909.1  striatin-3 isoform X2

      UniProtKB/TrEMBL
      A0AV58
    2. XM_054375935.1XP_054231910.1  striatin-3 isoform X3

      UniProtKB/TrEMBL
      A0AV58
    3. XM_054375933.1XP_054231908.1  striatin-3 isoform X1