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    ALG5 ALG5 dolichyl-phosphate beta-glucosyltransferase [ Homo sapiens (human) ]

    Gene ID: 29880, updated on 6-Nov-2022

    Summary

    Official Symbol
    ALG5provided by HGNC
    Official Full Name
    ALG5 dolichyl-phosphate beta-glucosyltransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:20266
    See related
    Ensembl:ENSG00000120697 MIM:604565; AllianceGenome:HGNC:20266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKD7; bA421P11.2
    Summary
    This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 27.6), colon (RPKM 17.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See ALG5 in Genome Data Viewer
    Location:
    13q13.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (36949738..36999367, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (36168907..36218563, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (37523875..37573504, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 pseudogene 28 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 5 Neighboring gene exosome component 8 Neighboring gene SPT20 homolog, SAGA complex component Neighboring gene casein kinase 1 alpha 1 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dolichyl-phosphate beta-glucosyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables oligosaccharyl transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in determination of left/right symmetry IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein N-linked glycosylation via asparagine TAS
    Traceable Author Statement
    more info
     
    involved_in protein glycosylation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    dolichyl-phosphate beta-glucosyltransferase
    Names
    Alg5, S. cerevisiae, homolog of
    asparagine-linked glycosylation 5 homolog (S. cerevisiae, dolichyl-phosphate beta-glucosyltransferase)
    asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase)
    asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog
    asparagine-linked glycosylation protein 5 homolog
    dolP-glucosyltransferase
    dolichyl phosphate glucosyltransferase
    NP_001135836.1
    NP_037470.1
    XP_047286239.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142364.1NP_001135836.1  dolichyl-phosphate beta-glucosyltransferase isoform 2

      See identical proteins and their annotated locations for NP_001135836.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter than isoform 1.
      Source sequence(s)
      AK299085, BP246765, BU739112
      Consensus CDS
      CCDS45033.1
      UniProtKB/Swiss-Prot
      Q9Y673
      Related
      ENSP00000390533.1, ENST00000443765.6
      Conserved Domains (1) summary
      cd04188
      Location:69259
      DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation
    2. NM_013338.5NP_037470.1  dolichyl-phosphate beta-glucosyltransferase isoform 1

      See identical proteins and their annotated locations for NP_037470.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL138706, BC012531, BP246765, BU739112
      Consensus CDS
      CCDS9361.1
      UniProtKB/Swiss-Prot
      Q5TBA6, Q9Y673
      Related
      ENSP00000239891.3, ENST00000239891.4
      Conserved Domains (1) summary
      cd04188
      Location:69289
      DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      36949738..36999367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430283.1XP_047286239.1  dolichyl-phosphate beta-glucosyltransferase isoform X1

      Related
      ENSP00000505408.1, ENST00000679673.1

    RNA

    1. XR_007063678.1 RNA Sequence

      Related
      ENST00000681581.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      36168907..36218563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)