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    Clic4 chloride intracellular channel 4 (mitochondrial) [ Mus musculus (house mouse) ]

    Gene ID: 29876, updated on 31-Jan-2019

    Summary

    Official Symbol
    Clic4provided by MGI
    Official Full Name
    chloride intracellular channel 4 (mitochondrial)provided by MGI
    Primary source
    MGI:MGI:1352754
    See related
    Ensembl:ENSMUSG00000037242
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TU-74; mc3s5; D0Jmb3; mtCLIC
    Expression
    Ubiquitous expression in lung adult (RPKM 93.5), bladder adult (RPKM 63.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Clic4 in Genome Data Viewer
    Location:
    4; 4 D3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (135213969..135272760, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (134769884..134828675, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 42327 Neighboring gene runt related transcription factor 3 Neighboring gene predicted gene, 30767 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    chloride transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endothelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    retina vasculature morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    chloride intracellular channel protein 4
    Names
    mc3s5/mtCLIC

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013885.2NP_038913.1  chloride intracellular channel protein 4

      See identical proteins and their annotated locations for NP_038913.1

      Status: PROVISIONAL

      Source sequence(s)
      AL627078, AL669936
      Consensus CDS
      CCDS18783.1
      UniProtKB/Swiss-Prot
      Q9QYB1
      UniProtKB/TrEMBL
      Q543N5
      Related
      ENSMUSP00000041453.8, ENSMUST00000037099.8
      Conserved Domains (1) summary
      TIGR00862
      Location:17252
      O-ClC; intracellular chloride channel protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      135213969..135272760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187024.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      192149..204672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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