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    Iqgap1 IQ motif containing GTPase activating protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 29875, updated on 4-Nov-2018

    Summary

    Official Symbol
    Iqgap1provided by MGI
    Official Full Name
    IQ motif containing GTPase activating protein 1provided by MGI
    Primary source
    MGI:MGI:1352757
    See related
    Ensembl:ENSMUSG00000030536 Vega:OTTMUSG00000058690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA682088; mKIAA0051; D7Ertd237e; D7Ertd257e
    Expression
    Ubiquitous expression in lung adult (RPKM 47.3), spleen adult (RPKM 27.7) and 27 other tissues See more
    Orthologs

    Genomic context

    See Iqgap1 in Genome Data Viewer
    Location:
    7 D3; 7 45.68 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (80711583..80815549, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (87856469..87948217, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 42398 Neighboring gene CREB regulated transcription coactivator 3 Neighboring gene predicted gene 15880 Neighboring gene predicted gene, 18392 Neighboring gene zinc finger and SCAN domain containing 2 Neighboring gene predicted gene, 32112 Neighboring gene WD repeat domain 73

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rac GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Rho GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to epidermal growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to fibroblast growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to platelet-derived growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of dephosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell leading edge IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribonucleoprotein complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras GTPase-activating-like protein IQGAP1
    Names
    Cdc42-Rac1 effector protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016721.2NP_057930.2  ras GTPase-activating-like protein IQGAP1

      See identical proteins and their annotated locations for NP_057930.2

      Status: VALIDATED

      Source sequence(s)
      AK160892, AK164482, BQ174517, BY107028, CB519254, DV069947
      Consensus CDS
      CCDS40001.1
      UniProtKB/Swiss-Prot
      Q9JKF1
      UniProtKB/TrEMBL
      Q3TPD2, Q3TU98
      Related
      ENSMUSP00000128278.1, OTTMUSP00000075167, ENSMUST00000167377.2, OTTMUST00000144162
      Conserved Domains (6) summary
      smart00015
      Location:774796
      IQ; Calmodulin-binding motif
      cd05133
      Location:10031382
      RasGAP_IQGAP1; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 1
      smart00323
      Location:9921344
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:45159
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00201
      Location:685712
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam03836
      Location:14521580
      RasGAP_C; RasGAP C-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      80711583..80815549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540950.3XP_006541013.2  ras GTPase-activating-like protein IQGAP1 isoform X1

      Conserved Domains (6) summary
      smart00015
      Location:798820
      IQ; Calmodulin-binding motif
      cd05133
      Location:10271406
      RasGAP_IQGAP1; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 1
      smart00323
      Location:10161368
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:69183
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00201
      Location:709736
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam03836
      Location:14761604
      RasGAP_C; RasGAP C-terminus

    RNA

    1. XR_001785567.1 RNA Sequence

    2. XR_391347.3 RNA Sequence

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