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    Scmh1 sex comb on midleg homolog 1 [ Mus musculus (house mouse) ]

    Gene ID: 29871, updated on 23-Jun-2021

    Summary

    Official Symbol
    Scmh1provided by MGI
    Official Full Name
    sex comb on midleg homolog 1provided by MGI
    Primary source
    MGI:MGI:1352762
    See related
    Ensembl:ENSMUSG00000000085
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scm; Scml1; Scml3; AI315320; AI851618
    Expression
    Ubiquitous expression in testis adult (RPKM 9.0), bladder adult (RPKM 6.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Scmh1 in Genome Data Viewer
    Location:
    4 D2.1; 4 56.52 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120262347..120387397)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120405150..120530200)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (120077886..120202804)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36499 Neighboring gene predicted gene, 36574 Neighboring gene VISTA enhancer mm145 Neighboring gene schlafen like 1 Neighboring gene cytidine 5'-triphosphate synthase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polycomb protein SCMH1
    Names
    sex comb on midleg 1
    sex comb on midleg-like 1
    sex comb on midleg-like 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159630.1NP_001153102.1  polycomb protein SCMH1 isoform 2

      See identical proteins and their annotated locations for NP_001153102.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL611924, AL626767
      Consensus CDS
      CCDS51292.1
      UniProtKB/Swiss-Prot
      Q8K214
      Related
      ENSMUSP00000101908.2, ENSMUST00000106301.8
      Conserved Domains (4) summary
      cd09578
      Location:591661
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:594661
      SAM; Sterile alpha motif
      smart00561
      Location:31126
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:357465
      DUF3588; Protein of unknown function (DUF3588)
    2. NM_001355423.1NP_001342352.1  polycomb protein SCMH1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AA273241, BM950146, CA319805, CD806648, CK329994, CN709475, CV562649, CV784512
      Consensus CDS
      CCDS18589.1
      Conserved Domains (4) summary
      cd09578
      Location:591661
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:31126
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:357465
      SLED; SLED domain
      pfam17208
      Location:270319
      RBR; RNA binding Region
    3. NM_001355424.1NP_001342353.1  polycomb protein SCMH1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA273241, BM950146, CA319805, CD806648, CK329994, CN709475, CV562649, CV784512
      Conserved Domains (4) summary
      cd09578
      Location:567637
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:7102
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:333441
      SLED; SLED domain
      pfam17208
      Location:246295
      RBR; RNA binding Region
    4. NM_001379184.1NP_001366113.1  polycomb protein SCMH1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL611924, AL626767
      Conserved Domains (4) summary
      cd09578
      Location:599669
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:39134
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:365473
      SLED; SLED domain
      pfam17208
      Location:278327
      RBR; RNA binding Region
    5. NM_001379185.1NP_001366114.1  polycomb protein SCMH1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL611924, AL626767
      Conserved Domains (4) summary
      cd09578
      Location:591661
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:31126
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:357465
      SLED; SLED domain
      pfam17208
      Location:270319
      RBR; RNA binding Region
    6. NM_001379186.1NP_001366115.1  polycomb protein SCMH1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL611924, AL626767
      Conserved Domains (4) summary
      cd09578
      Location:567637
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:7102
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:333441
      SLED; SLED domain
      pfam17208
      Location:246295
      RBR; RNA binding Region
    7. NM_013883.2NP_038911.1  polycomb protein SCMH1 isoform 1

      See identical proteins and their annotated locations for NP_038911.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1). Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AB030906, AL611924, AL626767
      Consensus CDS
      CCDS18589.1
      UniProtKB/Swiss-Prot
      Q8K214
      Related
      ENSMUSP00000000087.7, ENSMUST00000000087.13
      Conserved Domains (4) summary
      cd09578
      Location:591661
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:31126
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:357465
      SLED; SLED domain
      pfam17208
      Location:270319
      RBR; RNA binding Region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      120262347..120387397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503149.3XP_006503212.1  polycomb protein SCMH1 isoform X3

      Conserved Domains (4) summary
      smart00561
      Location:39134
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:365473
      SLED; SLED domain
      pfam17208
      Location:278327
      RBR; RNA binding Region
      cl15755
      Location:599636
      SAM_superfamily; SAM (Sterile alpha motif )
    2. XM_036164178.1XP_036020071.1  polycomb protein SCMH1 isoform X2

      Conserved Domains (4) summary
      cd09578
      Location:577647
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:39134
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:365473
      SLED; SLED domain
      pfam17208
      Location:278327
      RBR; RNA binding Region
    3. XM_030253600.1XP_030109460.1  polycomb protein SCMH1 isoform X4

      Conserved Domains (4) summary
      cd09578
      Location:530600
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:76174
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:296404
      SLED; SLED domain
      pfam17208
      Location:209258
      RBR; RNA binding Region
    4. XM_017320253.2XP_017175742.1  polycomb protein SCMH1 isoform X1

      UniProtKB/Swiss-Prot
      Q8K214
      Related
      ENSMUSP00000101905.4, ENSMUST00000106298.10
      Conserved Domains (4) summary
      cd09578
      Location:591661
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:31126
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:357465
      SLED; SLED domain
      pfam17208
      Location:270319
      RBR; RNA binding Region

    RNA

    1. XR_004941919.1 RNA Sequence

    2. XR_003954960.2 RNA Sequence

    3. XR_003954959.1 RNA Sequence

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