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    Bcar3 breast cancer anti-estrogen resistance 3 [ Mus musculus (house mouse) ]

    Gene ID: 29815, updated on 23-Jun-2021

    Summary

    Official Symbol
    Bcar3provided by MGI
    Official Full Name
    breast cancer anti-estrogen resistance 3provided by MGI
    Primary source
    MGI:MGI:1352501
    See related
    Ensembl:ENSMUSG00000028121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AND-; AND-34; AI131758
    Expression
    Ubiquitous expression in large intestine adult (RPKM 13.2), subcutaneous fat pad adult (RPKM 13.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Bcar3 in Genome Data Viewer
    Location:
    3; 3 G1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (122213406..122323840)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (122419757..122530191)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (122122698..122233101)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene predicted gene 4610 Neighboring gene predicted gene, 34349 Neighboring gene microRNA 7657 Neighboring gene formin binding protein 1-like Neighboring gene predicted gene 43568

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    breast cancer anti-estrogen resistance protein 3 homolog
    Names
    p130Cas-binding protein AND-34

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355264.1NP_001342193.1  breast cancer anti-estrogen resistance protein 3 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138720
      Conserved Domains (2) summary
      cd10337
      Location:57191
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:454729
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    2. NM_013867.3NP_038895.1  breast cancer anti-estrogen resistance protein 3 homolog isoform 1

      See identical proteins and their annotated locations for NP_038895.1

      Status: VALIDATED

      Source sequence(s)
      AC138720, AF179566, AV223564
      Consensus CDS
      CCDS17810.1
      UniProtKB/Swiss-Prot
      Q9QZK2
      Related
      ENSMUSP00000029766.5, ENSMUST00000029766.9
      Conserved Domains (2) summary
      cd10337
      Location:142276
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:539814
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      122213406..122323840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501559.5XP_006501622.1  breast cancer anti-estrogen resistance protein 3 homolog isoform X1

      Conserved Domains (1) summary
      cl02485
      Location:190465
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
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