Format

Send to:

Choose Destination
    • Showing Current items.

    Mga MAX gene associated [ Mus musculus (house mouse) ]

    Gene ID: 29808, updated on 31-Jan-2019

    Summary

    Official Symbol
    Mgaprovided by MGI
    Official Full Name
    MAX gene associatedprovided by MGI
    Primary source
    MGI:MGI:1352483
    See related
    Ensembl:ENSMUSG00000033943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mad5; C80739; AV312082; C130042M01Rik; D030062C11Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 3.0), CNS E11.5 (RPKM 2.8) and 26 other tissues See more
    Orthologs

    Genomic context

    See Mga in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (119871643..119970129)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (119722964..119795317)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RNA polymerase II associated protein 1 Neighboring gene TYRO3 protein tyrosine kinase 3 Neighboring gene fatty acid binding protein 5, epidermal pseudogene Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene microRNA 7665 Neighboring gene predicted gene, 28042 Neighboring gene jumonji domain containing 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    MAX gene-associated protein
    Names
    MAX-interacting protein
    Max dimerization protein 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164274.1NP_001157746.1  MAX gene-associated protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AL954662
      Consensus CDS
      CCDS50675.1
      UniProtKB/TrEMBL
      H7BX50
      Related
      ENSMUSP00000078853.5, ENSMUST00000079934.11
      Conserved Domains (3) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:21942244
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
    2. NM_013720.2NP_038748.2  MAX gene-associated protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF205935, AK046252, AK172962, AL954662, BQ552371, CD539587, CN725372
      Consensus CDS
      CCDS38208.1
      UniProtKB/Swiss-Prot
      A2AWL7
      UniProtKB/TrEMBL
      E9QLG3
      Related
      ENSMUSP00000106401.1, ENSMUST00000110774.7
      Conserved Domains (4) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:24032453
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
      pfam16640
      Location:15711655
      Big_3_5; Bacterial Ig-like domain (group 3)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      119871643..119970129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499691.3XP_006499754.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006499754.1

      Conserved Domains (4) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:24522502
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
      pfam16640
      Location:16201704
      Big_3_5; Bacterial Ig-like domain (group 3)
    2. XM_006499689.2XP_006499752.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006499752.1

      Conserved Domains (4) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:24522502
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
      pfam16640
      Location:16201704
      Big_3_5; Bacterial Ig-like domain (group 3)
    3. XM_006499687.3XP_006499750.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006499750.1

      Conserved Domains (4) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:24522502
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
      pfam16640
      Location:16201704
      Big_3_5; Bacterial Ig-like domain (group 3)
    4. XM_006499690.3XP_006499753.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006499753.1

      Conserved Domains (4) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:24522502
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
      pfam16640
      Location:16201704
      Big_3_5; Bacterial Ig-like domain (group 3)
    5. XM_011239591.1XP_011237893.1  MAX gene-associated protein isoform X5

      Conserved Domains (3) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:22442294
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
    6. XM_011239592.1XP_011237894.1  MAX gene-associated protein isoform X6

      Conserved Domains (3) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:21952245
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
    7. XM_006499688.3XP_006499751.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006499751.1

      Conserved Domains (4) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:24522502
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
      pfam16640
      Location:16201704
      Big_3_5; Bacterial Ig-like domain (group 3)
    8. XM_017318964.1XP_017174453.1  MAX gene-associated protein isoform X2

    9. XM_017318962.1XP_017174451.1  MAX gene-associated protein isoform X1

      Conserved Domains (4) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:24522502
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
      pfam16640
      Location:16201704
      Big_3_5; Bacterial Ig-like domain (group 3)
    10. XM_011239589.2XP_011237891.1  MAX gene-associated protein isoform X3

      Conserved Domains (4) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:23422392
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
      pfam16640
      Location:15101594
      Big_3_5; Bacterial Ig-like domain (group 3)
    11. XM_011239590.2XP_011237892.1  MAX gene-associated protein isoform X4

      Conserved Domains (4) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:22932343
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
      pfam16640
      Location:14611545
      Big_3_5; Bacterial Ig-like domain (group 3)
    12. XM_017318963.1XP_017174452.1  MAX gene-associated protein isoform X1

      Conserved Domains (4) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:24522502
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10381084
      DUF4801; Domain of unknown function (DUF4801)
      pfam16640
      Location:16201704
      Big_3_5; Bacterial Ig-like domain (group 3)
    13. XM_006499698.3XP_006499761.1  MAX gene-associated protein isoform X7

      See identical proteins and their annotated locations for XP_006499761.1

      Conserved Domains (2) summary
      pfam00010
      Location:908958
      HLH; Helix-loop-helix DNA-binding domain
      pfam16640
      Location:76160
      Big_3_5; Bacterial Ig-like domain (group 3)
    14. XM_006499697.2XP_006499760.1  MAX gene-associated protein isoform X7

      See identical proteins and their annotated locations for XP_006499760.1

      Conserved Domains (2) summary
      pfam00010
      Location:908958
      HLH; Helix-loop-helix DNA-binding domain
      pfam16640
      Location:76160
      Big_3_5; Bacterial Ig-like domain (group 3)

    RNA

    1. XR_866291.1 RNA Sequence

    2. XR_866290.2 RNA Sequence

    Support Center