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    Limd1 LIM domains containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 29806, updated on 8-Aug-2021

    Summary

    Official Symbol
    Limd1provided by MGI
    Official Full Name
    LIM domains containing 1provided by MGI
    Primary source
    MGI:MGI:1352502
    See related
    Ensembl:ENSMUSG00000025239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW822033; D9Ertd192; D9Ertd192e
    Expression
    Ubiquitous expression in large intestine adult (RPKM 22.1), spleen adult (RPKM 19.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Limd1 in Genome Data Viewer
    Location:
    9 F4; 9 74.0 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123306790..123350617)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123478661..123521552)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (123387819..123430670)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene leucyl-tRNA synthetase, mitochondrial Neighboring gene predicted gene, 46137 Neighboring gene predicted gene, 40586 Neighboring gene nuclear encoded tRNA arginine 2 (anticodon ACG) Neighboring gene SAC1 suppressor of actin mutations 1-like (yeast)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within P-body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene silencing by miRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    LIM domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013860.2NP_038888.2  LIM domain-containing protein 1

      See identical proteins and their annotated locations for NP_038888.2

      Status: VALIDATED

      Source sequence(s)
      AJ132409, AK047198, BC056449, BE199820, BY068411
      Consensus CDS
      CCDS23660.1
      UniProtKB/Swiss-Prot
      Q9QXD8
      Related
      ENSMUSP00000026269.3, ENSMUST00000026269.4
      Conserved Domains (3) summary
      cd09352
      Location:464517
      LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins
      cd09355
      Location:529581
      LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins
      cd09438
      Location:589650
      LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      123306790..123350617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155045.1XP_036010938.1  LIM domain-containing protein 1 isoform X1

      Conserved Domains (3) summary
      cd09355
      Location:495547
      LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins
      cd09438
      Location:555616
      LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins
      cl02475
      Location:462483
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    2. XM_036155046.1XP_036010939.1  LIM domain-containing protein 1 isoform X2

      Conserved Domains (2) summary
      PRK04654
      Location:92162
      PRK04654; sec-independent translocase; Provisional
      cl02475
      Location:464495
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    3. XM_011242977.3XP_011241279.1  LIM domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      PRK04654
      Location:92162
      PRK04654; sec-independent translocase; Provisional
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