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    TMOD2 tropomodulin 2 [ Homo sapiens (human) ]

    Gene ID: 29767, updated on 27-Nov-2024

    Summary

    Official Symbol
    TMOD2provided by HGNC
    Official Full Name
    tropomodulin 2provided by HGNC
    Primary source
    HGNC:HGNC:11872
    See related
    Ensembl:ENSG00000128872 MIM:602928; AllianceGenome:HGNC:11872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NTMOD; N-TMOD
    Summary
    This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008]
    Expression
    Biased expression in brain (RPKM 47.3), appendix (RPKM 3.6) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TMOD2 in Genome Data Viewer
    Location:
    15q21.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (51751597..51816363)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (49559103..49623854)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52043794..52108560)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12802 Neighboring gene secretogranin III Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9406 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6435 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6437 Neighboring gene LysM domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9407 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6438 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:52079467-52079967 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39634 Neighboring gene MPRA-validated peak2338 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr15:52121755-52121909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6441 Neighboring gene tropomodulin 3 Neighboring gene UTP6, small subunit (SSU) processome component, homolog (yeast) pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52178357-52179122 Neighboring gene RNA, U6 small nuclear 90, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC39481

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in learning or memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuron-neuron synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pointed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in striated muscle thin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tropomodulin-2
    Names
    neuronal tropomodulin
    tropomodulin 2 (neuronal)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142885.2NP_001136357.1  tropomodulin-2 isoform b

      See identical proteins and their annotated locations for NP_001136357.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded protein (isoform b) is shorter compared to isoform a.
      Source sequence(s)
      AC026770, AC090971, AK293823, DA808222
      Consensus CDS
      CCDS45260.1
      UniProtKB/TrEMBL
      A8K9L8
      Related
      ENSP00000404590.2, ENST00000435126.6
      Conserved Domains (2) summary
      cd00116
      Location:197287
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:5146
      Tropomodulin; Tropomodulin
    2. NM_014548.4NP_055363.1  tropomodulin-2 isoform a

      See identical proteins and their annotated locations for NP_055363.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC090971, BC064961, DA808222
      Consensus CDS
      CCDS10144.1
      UniProtKB/Swiss-Prot
      B4DEW6, Q9NZR1
      UniProtKB/TrEMBL
      A8K9L8
      Related
      ENSP00000249700.4, ENST00000249700.9
      Conserved Domains (2) summary
      pfam03250
      Location:5146
      Tropomodulin
      cl39015
      Location:215323
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      51751597..51816363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      49559103..49623854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)