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    BRD7 bromodomain containing 7 [ Homo sapiens (human) ]

    Gene ID: 29117, updated on 28-Oct-2024

    Summary

    Official Symbol
    BRD7provided by HGNC
    Official Full Name
    bromodomain containing 7provided by HGNC
    Primary source
    HGNC:HGNC:14310
    See related
    Ensembl:ENSG00000166164 MIM:618489; AllianceGenome:HGNC:14310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BP75; NAG4; CELTIX1; SMARCI1
    Summary
    This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in testis (RPKM 21.8), spleen (RPKM 16.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BRD7 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (50315957..50368988, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (56113791..56166835, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50349868..50402899, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:50186273-50187230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10809 Neighboring gene MPRA-validated peak2589 silencer Neighboring gene terminal nucleotidyltransferase 4B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50217888-50218450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50218451-50219012 Neighboring gene Sharpr-MPRA regulatory region 14159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10810 Neighboring gene Sharpr-MPRA regulatory region 8986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50278238-50278950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50278951-50279662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50280376-50281087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50288095-50288594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50299606-50300199 Neighboring gene adenylate cyclase 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50305212-50306046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50306047-50306881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50317845-50318346 Neighboring gene Sharpr-MPRA regulatory region 2137 Neighboring gene microRNA 6771 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:50347343-50348542 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:50353005-50354204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10816 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7482 Neighboring gene Sharpr-MPRA regulatory region 13482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10817 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:50430839-50432038 Neighboring gene long intergenic non-protein coding RNA 2178 Neighboring gene uncharacterized LOC124903770

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of myoblast differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of G0 to G1 transition NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of nucleotide-excision repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in chromatin NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nuclear matrix NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    bromodomain-containing protein 7
    Names
    75 kDa bromodomain protein
    protein CELTIX-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023418.2 RefSeqGene

      Range
      5000..58031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001173984.3NP_001167455.1  bromodomain-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_001167455.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC007493, AC007597, AF152604, AF213969, AW615116
      Consensus CDS
      CCDS54007.1
      UniProtKB/TrEMBL
      A0AA34QW01
      Related
      ENSP00000378181.2, ENST00000394689.2
      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287533
      DUF3512; Domain of unknown function (DUF3512)
    2. NM_013263.5NP_037395.2  bromodomain-containing protein 7 isoform 2

      See identical proteins and their annotated locations for NP_037395.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
      Source sequence(s)
      AC007493, AC007597, AF152604, AW615116, DA645362
      Consensus CDS
      CCDS10742.1
      UniProtKB/Swiss-Prot
      Q4VC09, Q8N2L9, Q96KA4, Q9BV48, Q9NPI1, Q9UH59
      UniProtKB/TrEMBL
      A0AA34QW01
      Related
      ENSP00000378180.3, ENST00000394688.8
      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287532
      DUF3512; Domain of unknown function (DUF3512)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      50315957..50368988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023180.2XP_016878669.1  bromodomain-containing protein 7 isoform X6

      UniProtKB/TrEMBL
      A0AA34QW01
    2. XM_017023179.2XP_016878668.1  bromodomain-containing protein 7 isoform X5

      UniProtKB/TrEMBL
      A0AA34QW01
    3. XM_011523049.3XP_011521351.1  bromodomain-containing protein 7 isoform X4

      UniProtKB/TrEMBL
      A0AA34QW01
      Conserved Domains (2) summary
      cd05513
      Location:152249
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:304513
      DUF3512; Domain of unknown function (DUF3512)
    4. XM_011523048.3XP_011521350.1  bromodomain-containing protein 7 isoform X3

      UniProtKB/TrEMBL
      A0AA34QW01
      Conserved Domains (2) summary
      cd05513
      Location:152249
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:304514
      DUF3512; Domain of unknown function (DUF3512)
    5. XM_011523047.3XP_011521349.1  bromodomain-containing protein 7 isoform X2

      UniProtKB/TrEMBL
      A0AA34QVS2, A0AA34QW01
      Related
      ENSP00000518227.1, ENST00000710356.1
      Conserved Domains (2) summary
      cd05513
      Location:152249
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:304549
      DUF3512; Domain of unknown function (DUF3512)
    6. XM_011523046.4XP_011521348.1  bromodomain-containing protein 7 isoform X1

      UniProtKB/TrEMBL
      A0AA34QW01
      Conserved Domains (2) summary
      cd05513
      Location:152249
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:304550
      DUF3512; Domain of unknown function (DUF3512)
    7. XM_047434006.1XP_047289962.1  bromodomain-containing protein 7 isoform X7

    8. XM_011523050.4XP_011521352.1  bromodomain-containing protein 7 isoform X10

      Conserved Domains (2) summary
      pfam12024
      Location:85331
      DUF3512; Domain of unknown function (DUF3512)
      cl02556
      Location:130
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    9. XM_047434008.1XP_047289964.1  bromodomain-containing protein 7 isoform X9

    10. XM_047434007.1XP_047289963.1  bromodomain-containing protein 7 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      56113791..56166835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380174.1XP_054236149.1  bromodomain-containing protein 7 isoform X6

    2. XM_054380173.1XP_054236148.1  bromodomain-containing protein 7 isoform X5

    3. XM_054380172.1XP_054236147.1  bromodomain-containing protein 7 isoform X4

    4. XM_054380171.1XP_054236146.1  bromodomain-containing protein 7 isoform X3

    5. XM_054380170.1XP_054236145.1  bromodomain-containing protein 7 isoform X2

      UniProtKB/TrEMBL
      A0AA34QVS2
    6. XM_054380169.1XP_054236144.1  bromodomain-containing protein 7 isoform X1

    7. XM_054380175.1XP_054236150.1  bromodomain-containing protein 7 isoform X7

    8. XM_054380178.1XP_054236153.1  bromodomain-containing protein 7 isoform X10

    9. XM_054380177.1XP_054236152.1  bromodomain-containing protein 7 isoform X9

    10. XM_054380176.1XP_054236151.1  bromodomain-containing protein 7 isoform X8