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    WDR91 WD repeat domain 91 [ Homo sapiens (human) ]

    Gene ID: 29062, updated on 17-Jun-2024

    Summary

    Official Symbol
    WDR91provided by HGNC
    Official Full Name
    WD repeat domain 91provided by HGNC
    Primary source
    HGNC:HGNC:24997
    See related
    Ensembl:ENSG00000105875 MIM:616303; AllianceGenome:HGNC:24997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SORF1; SORF-1; HSPC049
    Summary
    Enables phosphatidylinositol 3-kinase regulator activity. Involved in early endosome to late endosome transport; regulation of cellular protein catabolic process; and regulation of phosphatidylinositol 3-kinase activity. Located in cytosol; early endosome membrane; and late endosome membrane. Is extrinsic component of endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney (RPKM 8.1), placenta (RPKM 7.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See WDR91 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (135183839..135211526, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (136491701..136519383, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134868591..134896278, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene AGBL carboxypeptidase 3 Neighboring gene cell cycle regulator of NHEJ Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26702 Neighboring gene RNF14 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18676 Neighboring gene transmembrane protein 140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26711 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:134877948-134879147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26712 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134888580-134888794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18677 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134893611-134894810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18678 Neighboring gene microRNA 6509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26713 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134935285-134935435 Neighboring gene uncharacterized LOC107984123 Neighboring gene stimulated by retinoic acid 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26714 Neighboring gene solute carrier family 23 member 4, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of WD repeat domain 91 (WDR91; HSPC049) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol 3-kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphatidylinositol 3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WD repeat-containing protein 91

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362736.2NP_001349665.1  WD repeat-containing protein 91 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009542, AC083862, BC017246
      UniProtKB/TrEMBL
      C9J1X0
      Conserved Domains (3) summary
      sd00039
      Location:505576
      7WD40; WD40 repeat [structural motif]
      pfam12881
      Location:253343
      NUT; NUT protein
      cl25539
      Location:407758
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001362737.2NP_001349666.1  WD repeat-containing protein 91 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC009542, AC083862, BC017246, BG767291
      UniProtKB/TrEMBL
      C9J1X0
      Conserved Domains (3) summary
      sd00039
      Location:454510
      7WD40; WD40 repeat [structural motif]
      pfam12881
      Location:253343
      NUT; NUT protein
      cl25539
      Location:407765
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001362738.2NP_001349667.1  WD repeat-containing protein 91 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC009542, AC083862, BC017246, DA634150
      Conserved Domains (3) summary
      sd00039
      Location:243314
      7WD40; WD40 repeat [structural motif]
      pfam12881
      Location:9100
      NUT; NUT protein
      cl25539
      Location:164496
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_014149.4NP_054868.3  WD repeat-containing protein 91 isoform 3

      See identical proteins and their annotated locations for NP_054868.3

      Status: VALIDATED

      Source sequence(s)
      AC009542, AC083862, BC017246
      Consensus CDS
      CCDS34758.1
      UniProtKB/Swiss-Prot
      A4D1P6, A6NK54, C9JMI4, Q6FI65, Q6MZQ1, Q6P4I1, Q96AE5, Q96G63, Q9H062, Q9H9B6, Q9NVG7, Q9NZY6
      UniProtKB/TrEMBL
      C9J1X0
      Related
      ENSP00000346466.4, ENST00000354475.5
      Conserved Domains (3) summary
      sd00039
      Location:486557
      7WD40; WD40 repeat [structural motif]
      pfam12881
      Location:253343
      NUT; NUT protein
      cl25539
      Location:407739
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_156130.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009542, AC083862, AK022935
      Related
      ENST00000684339.1
    2. NR_156131.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009542, AC083862, BC017246, DA634150
      Related
      ENST00000684322.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      135183839..135211526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420266.1XP_047276222.1  WD repeat-containing protein 91 isoform X1

      Related
      ENSP00000508083.1, ENST00000683947.1
    2. XM_047420267.1XP_047276223.1  WD repeat-containing protein 91 isoform X2

      UniProtKB/TrEMBL
      A0A804HI90
      Related
      ENSP00000506955.1, ENST00000682250.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      136491701..136519383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357997.1XP_054213972.1  WD repeat-containing protein 91 isoform X1

    2. XM_054357998.1XP_054213973.1  WD repeat-containing protein 91 isoform X2

      UniProtKB/TrEMBL
      A0A804HI90