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    ATAD2 ATPase family AAA domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 29028, updated on 28-Oct-2024

    Summary

    Official Symbol
    ATAD2provided by HGNC
    Official Full Name
    ATPase family AAA domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:30123
    See related
    Ensembl:ENSG00000156802 MIM:611941; AllianceGenome:HGNC:30123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANCCA; CT137; PRO2000
    Summary
    A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 15.3), bone marrow (RPKM 13.1) and 23 other tissues See more
    Orthologs
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    Genomic context

    See ATAD2 in Genome Data Viewer
    Location:
    8q24.13
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (123319850..123416350, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (124450947..124547457, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124332090..124408687, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ZHX1-C8orf76 readthrough Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:124285783-124286150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27871 Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene hydroxysteroid 17-beta dehydrogenase 4 pseudogene Neighboring gene Sharpr-MPRA regulatory region 1385 Neighboring gene RNA, U6 small nuclear 875, pseudogene Neighboring gene microRNA 548aa-1 Neighboring gene microRNA 548d-1 Neighboring gene deoxyuridine triphosphatase pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:124405259-124405759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19498 Neighboring gene Sharpr-MPRA regulatory region 2006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:124422560-124423060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:124423061-124423561 Neighboring gene MPRA-validated peak7156 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19499 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:124429186-124429780 Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 6 Neighboring gene N-terminal glutamine amidase 1 Neighboring gene uncharacterized LOC124902105 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:124491440-124491940 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:124491941-124492441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:124518725-124519269 Neighboring gene F-box protein 32 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:124539974-124541173 Neighboring gene MPRA-validated peak7157 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19502

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC5254, MGC29843, MGC131938, MGC142216, DKFZp667N1320

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nucleosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATPase family AAA domain-containing protein 2
    Names
    AAA nuclear coregulator cancer-associated protein
    NP_054828.2
    XP_011515296.1
    XP_011515297.1
    XP_011515298.1
    XP_047277678.1
    XP_047277679.1
    XP_047277680.1
    XP_047277681.1
    XP_054216337.1
    XP_054216338.1
    XP_054216339.1
    XP_054216340.1
    XP_054216341.1
    XP_054216342.1
    XP_054216343.1
    XP_054216344.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014109.4NP_054828.2  ATPase family AAA domain-containing protein 2

      See identical proteins and their annotated locations for NP_054828.2

      Status: REVIEWED

      Source sequence(s)
      BC113656, BP314109, CA441499, CB159561
      Consensus CDS
      CCDS6343.1
      UniProtKB/Swiss-Prot
      Q14CR1, Q658P2, Q68CQ0, Q6PJV6, Q6PL18, Q8N890, Q9UHS5
      Related
      ENSP00000287394.5, ENST00000287394.10
      Conserved Domains (4) summary
      cd05528
      Location:9871097
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:459600
      AAA; ATPases associated with a variety of cellular activities
      COG5076
      Location:9151153
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00004
      Location:464598
      AAA; ATPase family associated with various cellular activities (AAA)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      123319850..123416350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421723.1XP_047277679.1  ATPase family AAA domain-containing protein 2 isoform X2

    2. XM_047421722.1XP_047277678.1  ATPase family AAA domain-containing protein 2 isoform X2

    3. XM_011516994.4XP_011515296.1  ATPase family AAA domain-containing protein 2 isoform X1

      Conserved Domains (4) summary
      cd05528
      Location:9871097
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:459600
      AAA; ATPases associated with a variety of cellular activities
      COG5076
      Location:9151160
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00004
      Location:464598
      AAA; ATPase family associated with various cellular activities (AAA)
    4. XM_011516996.4XP_011515298.1  ATPase family AAA domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0B4J211
      Related
      ENSP00000429213.1, ENST00000521903.5
      Conserved Domains (2) summary
      cd05528
      Location:446556
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      cl21455
      Location:1757
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    5. XM_047421724.1XP_047277680.1  ATPase family AAA domain-containing protein 2 isoform X5

    6. XM_011516995.4XP_011515297.1  ATPase family AAA domain-containing protein 2 isoform X3

      Related
      ENST00000521496.5
      Conserved Domains (2) summary
      smart00382
      Location:459600
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:464598
      AAA; ATPase family associated with various cellular activities (AAA)
    7. XM_047421725.1XP_047277681.1  ATPase family AAA domain-containing protein 2 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      124450947..124547457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360364.1XP_054216339.1  ATPase family AAA domain-containing protein 2 isoform X2

    2. XM_054360363.1XP_054216338.1  ATPase family AAA domain-containing protein 2 isoform X2

    3. XM_054360362.1XP_054216337.1  ATPase family AAA domain-containing protein 2 isoform X1

    4. XM_054360365.1XP_054216340.1  ATPase family AAA domain-containing protein 2 isoform X2

    5. XM_054360367.1XP_054216342.1  ATPase family AAA domain-containing protein 2 isoform X4

    6. XM_054360368.1XP_054216343.1  ATPase family AAA domain-containing protein 2 isoform X5

    7. XM_054360366.1XP_054216341.1  ATPase family AAA domain-containing protein 2 isoform X3

    8. XM_054360369.1XP_054216344.1  ATPase family AAA domain-containing protein 2 isoform X6