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    MACROD1 mono-ADP ribosylhydrolase 1 [ Homo sapiens (human) ]

    Gene ID: 28992, updated on 5-Mar-2024

    Summary

    Official Symbol
    MACROD1provided by HGNC
    Official Full Name
    mono-ADP ribosylhydrolase 1provided by HGNC
    Primary source
    HGNC:HGNC:29598
    See related
    Ensembl:ENSG00000133315 MIM:610400; AllianceGenome:HGNC:29598
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRP16
    Summary
    Enables ADP-ribosylglutamate hydrolase activity and deacetylase activity. Involved in cellular response to DNA damage stimulus; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney (RPKM 9.5), prostate (RPKM 2.7) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MACROD1 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63998558..64166113, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63988261..64156074, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63766030..63933585, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63744743-63745420 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63746097-63746774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3453 Neighboring gene cytochrome c oxidase subunit 8A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63764275-63765212 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63766149-63767086 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:63767087-63768022 and GRCh37_chr11:63768035-63768542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63775344-63775934 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63789022-63789720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63789721-63790419 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63791118-63791816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63795215-63796016 Neighboring gene uncharacterized LOC124902685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63803443-63804345 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63804346-63805247 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63815687-63816245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63816558-63817058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63820013-63820556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63820557-63821100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63821645-63822187 Neighboring gene fibronectin leucine rich transmembrane protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63826482-63827200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63836633-63837360 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:63840775-63840963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63860723-63861393 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63861723-63862230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63877842-63878622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63889359-63890290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63896949-63897542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63913439-63913940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63919856-63920851 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63920852-63921846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63933104-63933604 Neighboring gene uncharacterized LOC105369339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3460 Neighboring gene MPRA-validated peak1294 silencer Neighboring gene uncharacterized LOC124902686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63948751-63949252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63949253-63949752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63951637-63952142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3461 Neighboring gene stress induced phosphoprotein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP-ribosylglutamate hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ADP-ribosylglutamate hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydrolase activity, acting on glycosyl bonds IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-glutamate ADP-deribosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-glutamate ADP-deribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein de-ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in purine nucleoside metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in purine nucleoside metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ADP-ribose glycohydrolase MACROD1
    Names
    MACRO domain containing 1
    MACRO domain-containing protein 1
    O-acetyl-ADP-ribose deacetylase MACROD1
    [Protein ADP-ribosylaspartate] hydrolase MACROD1
    [Protein ADP-ribosylglutamate] hydrolase
    [Protein ADP-ribosylglutamate] hydrolase MACROD1
    NP_001397948.1
    NP_054786.2
    XP_005273997.1
    XP_006718584.1
    XP_006718585.1
    XP_011543272.1
    XP_054224541.1
    XP_054224542.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411019.1NP_001397948.1  ADP-ribose glycohydrolase MACROD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP000721, AP006333
      Consensus CDS
      CCDS91496.1
      UniProtKB/TrEMBL
      A0A6Q8PH91
      Related
      ENSP00000502549.1, ENST00000675777.1
    2. NM_014067.4NP_054786.2  ADP-ribose glycohydrolase MACROD1 isoform 1

      See identical proteins and their annotated locations for NP_054786.2

      Status: VALIDATED

      Source sequence(s)
      AF202922, BC003188, BQ637198
      Consensus CDS
      CCDS8056.1
      UniProtKB/Swiss-Prot
      Q9BQ69, Q9UH96
      Related
      ENSP00000255681.6, ENST00000255681.7
      Conserved Domains (2) summary
      COG2110
      Location:152314
      YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
      cd02908
      Location:153319
      Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      63998558..64166113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544970.3XP_011543272.1  ADP-ribose glycohydrolase MACROD1 isoform X1

      Conserved Domains (1) summary
      PRK00431
      Location:153308
      PRK00431; ADP-ribose-binding protein
    2. XM_006718521.4XP_006718584.1  ADP-ribose glycohydrolase MACROD1 isoform X2

      Conserved Domains (1) summary
      cl00019
      Location:153177
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
    3. XM_006718522.3XP_006718585.1  ADP-ribose glycohydrolase MACROD1 isoform X4

      Conserved Domains (1) summary
      cl00019
      Location:153172
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
    4. XM_005273940.3XP_005273997.1  ADP-ribose glycohydrolase MACROD1 isoform X3

      Related
      ENST00000538595.1
      Conserved Domains (1) summary
      cl00019
      Location:153172
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      63988261..64156074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368566.1XP_054224541.1  ADP-ribose glycohydrolase MACROD1 isoform X1

    2. XM_054368567.1XP_054224542.1  ADP-ribose glycohydrolase MACROD1 isoform X3