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    MRPS18B mitochondrial ribosomal protein S18B [ Homo sapiens (human) ]

    Gene ID: 28973, updated on 17-Jun-2024

    Summary

    Official Symbol
    MRPS18Bprovided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S18Bprovided by HGNC
    Primary source
    HGNC:HGNC:14516
    See related
    Ensembl:ENSG00000204568 MIM:611982; AllianceGenome:HGNC:14516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    mS40; PTD017; S18amt; C6orf14; HSPC183; MRPS18-2; HumanS18a; MRP-S18-2
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 30.3), thyroid (RPKM 26.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MRPS18B in Genome Data Viewer
    Location:
    6p21.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30617840..30626392)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30482021..30490573)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30585617..30594169)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily F member 1 Neighboring gene microRNA 877 Neighboring gene protein phosphatase 1 regulatory subunit 10 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:30577096-30578295 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30585278-30585846 Neighboring gene Sharpr-MPRA regulatory region 13793 Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene prothymosin alpha pseudogene 1 Neighboring gene chromosome 6 open reading frame 136 Neighboring gene DEAH-box helicase 16

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp564H0223

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    part_of mitochondrial small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    small ribosomal subunit protein mS40
    Names
    28S ribosomal protein S18-2, mitochondrial
    28S ribosomal protein S18b, mitochondrial
    MRP-S18-b
    S18mt-b
    mitochondrial ribosomal protein S18-2
    mitochondrial small ribosomal subunit protein bS18b
    mitochondrial small ribosomal subunit protein bS18m-B
    mitochondrial small ribosomal subunit protein mS40
    mrps18-b
    small ribosomal subunit protein bS18b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014046.4NP_054765.1  small ribosomal subunit protein mS40

      See identical proteins and their annotated locations for NP_054765.1

      Status: REVIEWED

      Source sequence(s)
      AF100761, BE220785, BG773408
      Consensus CDS
      CCDS4682.1
      UniProtKB/Swiss-Prot
      A6NDQ0, Q659G4, Q9BS27, Q9Y676
      UniProtKB/TrEMBL
      A0A1U9X819, B0S7P4
      Related
      ENSP00000259873.4, ENST00000259873.5
      Conserved Domains (1) summary
      pfam01084
      Location:111163
      Ribosomal_S18; Ribosomal protein S18

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      30617840..30626392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446408.2XP_024302176.2  small ribosomal subunit protein mS40 isoform X1

      UniProtKB/TrEMBL
      B4DFG6

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      2097564..2106116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329798.1XP_054185773.1  small ribosomal subunit protein mS40 isoform X1

      UniProtKB/TrEMBL
      B4DFG6

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      1873670..1882222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330286.1XP_054186261.1  small ribosomal subunit protein mS40 isoform X1

      UniProtKB/TrEMBL
      B4DFG6

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      1928069..1936621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330577.1XP_054186552.1  small ribosomal subunit protein mS40 isoform X1

      UniProtKB/TrEMBL
      B4DFG6

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      1961888..1970440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330803.1XP_054186778.1  small ribosomal subunit protein mS40 isoform X1

      UniProtKB/TrEMBL
      B4DFG6

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      1872928..1881480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      1918598..1927150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331318.1XP_054187293.1  small ribosomal subunit protein mS40 isoform X1

      UniProtKB/TrEMBL
      B4DFG6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      30482021..30490573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355242.1XP_054211217.1  small ribosomal subunit protein mS40 isoform X1

      UniProtKB/TrEMBL
      B4DFG6