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    AAMDC adipogenesis associated Mth938 domain containing [ Homo sapiens (human) ]

    Gene ID: 28971, updated on 23-Nov-2021

    Summary

    Official Symbol
    AAMDCprovided by HGNC
    Official Full Name
    adipogenesis associated Mth938 domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:30205
    See related
    Ensembl:ENSG00000087884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CK067; PTD015; C11orf67
    Expression
    Ubiquitous expression in adrenal (RPKM 14.7), fat (RPKM 11.2) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See AAMDC in Genome Data Viewer
    Location:
    11q14.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (77821144..77906024)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77532190..77611819)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene remodeling and spacing factor 1 Neighboring gene ferritin heavy chain 1 pseudogene 16 Neighboring gene ribosomal protein S20 pseudogene 27 Neighboring gene ribosomal protein L21 pseudogene 95 Neighboring gene integrator complex subunit 4 Neighboring gene NDUFC2-KCTD14 readthrough Neighboring gene potassium channel tetramerization domain containing 14 Neighboring gene NADH:ubiquinone oxidoreductase subunit C2 Neighboring gene thyroid hormone responsive

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC3367, FLJ21035

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    mth938 domain-containing protein
    Names
    UPF0366 protein C11orf67
    adipogenesis associated Mth938 domain-containing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316957.3NP_001303886.1  mth938 domain-containing protein isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AP000580, AP002812
      Consensus CDS
      CCDS81605.1
      UniProtKB/Swiss-Prot
      Q9H7C9
      UniProtKB/TrEMBL
      K4DI89
      Related
      ENSP00000307254.8, ENST00000304716.12
      Conserved Domains (1) summary
      cd05126
      Location:593
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    2. NM_001316958.3NP_001303887.1  mth938 domain-containing protein isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 12 both encode the same isoform (b).
      Source sequence(s)
      AP000580, AP002812
      Consensus CDS
      CCDS81604.1
      UniProtKB/TrEMBL
      E9PLK9
      Related
      ENSP00000433281.1, ENST00000527134.5
      Conserved Domains (1) summary
      cl00182
      Location:593
      Mth938-like; Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a ...
    3. NM_001316960.2NP_001303889.1  mth938 domain-containing protein isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has an alternate exon in place of the last two exons compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a. Variants 3-6 and 13-16 all encode the same isoform (c).
      Source sequence(s)
      BC002752, BI791786, BP270361
      Consensus CDS
      CCDS8254.1
      UniProtKB/Swiss-Prot
      Q9H7C9
      Conserved Domains (1) summary
      cd05126
      Location:5120
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    4. NM_001316961.2NP_001303890.1  mth938 domain-containing protein isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has an alternate exon in place of the last two exons compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a. Variants 3-6 and 13-16 all encode the same isoform (c).
      Source sequence(s)
      AI569731, AP002812, BC002752, BP270361
      Consensus CDS
      CCDS8254.1
      UniProtKB/Swiss-Prot
      Q9H7C9
      Conserved Domains (1) summary
      cd05126
      Location:5120
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    5. NM_001316962.2NP_001303891.1  mth938 domain-containing protein isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has an alternate exon in place of the last two exons compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a. Variants 3-6 and 13-16 all encode the same isoform (c).
      Source sequence(s)
      BM930331, BP270361
      Consensus CDS
      CCDS8254.1
      UniProtKB/Swiss-Prot
      Q9H7C9
      Related
      ENSP00000431808.1, ENST00000526415.5
      Conserved Domains (1) summary
      cd05126
      Location:5120
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    6. NM_001363564.2NP_001350493.2  mth938 domain-containing protein isoform d

      Status: VALIDATED

      Source sequence(s)
      AP002812
      Consensus CDS
      CCDS86232.1
      Related
      ENSP00000432830.1, ENST00000525034.1
      Conserved Domains (1) summary
      cd05126
      Location:5120
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    7. NM_001392031.1NP_001378960.1  mth938 domain-containing protein isoform e

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP002812
      Conserved Domains (1) summary
      cd05126
      Location:5166
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    8. NM_001392032.1NP_001378961.1  mth938 domain-containing protein isoform e

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP002812
      Conserved Domains (1) summary
      cd05126
      Location:5166
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    9. NM_001392033.1NP_001378962.1  mth938 domain-containing protein isoform e

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP002812
      Related
      ENSP00000436086.1, ENST00000533193.5
      Conserved Domains (1) summary
      cd05126
      Location:5166
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    10. NM_001392034.1NP_001378963.1  mth938 domain-containing protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP002812
      Conserved Domains (1) summary
      cl00182
      Location:593
      Mth938-like; Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a ...
    11. NM_001392035.1NP_001378964.1  mth938 domain-containing protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP002812
      Conserved Domains (1) summary
      cd05126
      Location:5120
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    12. NM_001392036.1NP_001378965.1  mth938 domain-containing protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP002812
      Conserved Domains (1) summary
      cd05126
      Location:5120
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    13. NM_001392037.1NP_001378966.1  mth938 domain-containing protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP002812
      Conserved Domains (1) summary
      cd05126
      Location:5120
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    14. NM_001392038.1NP_001378967.1  mth938 domain-containing protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP002812
      Conserved Domains (1) summary
      cd05126
      Location:5120
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
    15. NM_001392068.1NP_001378997.1  mth938 domain-containing protein isoform f

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP002812
      Conserved Domains (1) summary
      cl00182
      Location:576
      Mth938-like; Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a ...
    16. NM_024684.4NP_078960.1  mth938 domain-containing protein isoform c

      See identical proteins and their annotated locations for NP_078960.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has an alternate exon in place of the last two exons compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a. Variants 3-6 and 13-16 all encode the same isoform (c).
      Source sequence(s)
      BC002752, BP270361
      Consensus CDS
      CCDS8254.1
      UniProtKB/Swiss-Prot
      Q9H7C9
      Related
      ENSP00000377078.2, ENST00000393427.6
      Conserved Domains (1) summary
      cd05126
      Location:5120
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...

    RNA

    1. NR_133637.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate 5' exon and an alternate 3' exon, and contains another alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000580, AP002812
    2. NR_171640.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP002812
    3. NR_171642.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP002812
    4. NR_171643.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000580, AP002812

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      77821144..77906024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017620.1XP_016873109.1  mth938 domain-containing protein isoform X3

      Conserved Domains (1) summary
      cd05126
      Location:24112
      Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
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