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    MRPS28 mitochondrial ribosomal protein S28 [ Homo sapiens (human) ]

    Gene ID: 28957, updated on 19-Sep-2024

    Summary

    Official Symbol
    MRPS28provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S28provided by HGNC
    Primary source
    HGNC:HGNC:14513
    See related
    Ensembl:ENSG00000147586 MIM:611990; AllianceGenome:HGNC:14513
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRPS35; COXPD47; HSPC007; MRP-S28; MRP-S35
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 38.5), heart (RPKM 29.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See MRPS28 in Genome Data Viewer
    Location:
    8q21.13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (79918717..80030259, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (80350048..80461598, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (80830952..80942494, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19313 Neighboring gene uncharacterized LOC101927040 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:80695841-80696641 Neighboring gene long intergenic non-protein coding RNA 1607 Neighboring gene U7 small nuclear RNA Neighboring gene hes related family bHLH transcription factor with YRPW motif 1 Neighboring gene RNA, U7 small nuclear 85 pseudogene Neighboring gene Sharpr-MPRA regulatory region 4298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19315 Neighboring gene uncharacterized LOC124901966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19316 Neighboring gene TPD52-MRPS28 readthrough Neighboring gene VISTA enhancer hs1305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:80894241-80894806 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:80909347-80909896 Neighboring gene Sharpr-MPRA regulatory region 4480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19317 Neighboring gene Sharpr-MPRA regulatory region 3052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27553 Neighboring gene tumor protein D52 Neighboring gene uncharacterized LOC105375919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19318 Neighboring gene uncharacterized LOC105375918

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev is identified to have a physical interaction with mitochondrial ribosomal protein S28 (MRPS28) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    small ribosomal subunit protein bS1m
    Names
    28S ribosomal protein S28, mitochondrial
    28S ribosomal protein S35, mitochondrial
    S28mt
    S35mt
    mitochondrial 28S ribosomal protein S35
    mitochondrial small ribosomal subunit protein bS1m

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014018.3NP_054737.1  small ribosomal subunit protein bS1m

      See identical proteins and their annotated locations for NP_054737.1

      Status: REVIEWED

      Source sequence(s)
      AC036214, BC010150
      Consensus CDS
      CCDS6226.1
      UniProtKB/Swiss-Prot
      B2RDZ7, Q96Q21, Q9Y2Q9
      UniProtKB/TrEMBL
      A0A0S2Z563, Q53G62
      Related
      ENSP00000276585.4, ENST00000276585.9
      Conserved Domains (1) summary
      pfam10246
      Location:74178
      MRP-S35; Mitochondrial ribosomal protein MRP-S35

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      79918717..80030259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      80350048..80461598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)