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    GRIA1 glutamate ionotropic receptor AMPA type subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2890, updated on 10-Dec-2024

    Summary

    Official Symbol
    GRIA1provided by HGNC
    Official Full Name
    glutamate ionotropic receptor AMPA type subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:4571
    See related
    Ensembl:ENSG00000155511 MIM:138248; AllianceGenome:HGNC:4571
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLUH1; GLUR1; GLURA; GluA1; HBGR1; MRD67; MRT76
    Summary
    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 23.3) and lung (RPKM 3.7) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GRIA1 in Genome Data Viewer
    Location:
    5q33.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (153489615..153813869)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (154022776..154347051)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (152870230..153193429)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr5:152022318-152022903 Neighboring gene tRNA-Cys (anticodon ACA) 1-1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:152038685-152039224 Neighboring gene long intergenic non-protein coding RNA 1470 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83100 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83142 Neighboring gene uncharacterized LOC124901117 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83185 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:152147932-152148511 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:152191225-152192424 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83374 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83428 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83450 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:152415832-152416029 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:152455744-152456284 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83469 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83487 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:152685418-152686617 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:152729354-152730121 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:152731661-152732860 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:152730122-152730888 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:152829283-152830143 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:152835859-152836432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16531 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:153162167-153162715 Neighboring gene NANOG hESC enhancer GRCh37_chr5:153170808-153171397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16532 Neighboring gene RNA, 7SL, cytoplasmic 177, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:153204359-153204899 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:153320112-153321311 Neighboring gene long intergenic non-protein coding RNA 1861 Neighboring gene uncharacterized LOC107986464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:153338304-153338911 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:153338912-153339518 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:153339519-153340125

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Intellectual developmental disorder, autosomal dominant 67
    MedGen: C5677006 OMIM: 619927 GeneReviews: Not available
    Compare labs
    Intellectual developmental disorder, autosomal recessive 76
    MedGen: C5677007 OMIM: 619931 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study of aging.
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    EBI GWAS Catalog
    Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
    EBI GWAS Catalog
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of glutamate receptor 1 is significantly upregulated in clade B Tat treated SK-N-MC neuroblastoma cells PubMed
    tat HIV-1 Tat-induced dendritic swellings that act in striatal neurons are regulated by NMDA and AMPA receptor-related events PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC133252

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables AMPA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables AMPA glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables AMPA glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G-protein alpha-subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables adenylate cyclase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables beta-2 adrenergic receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutamate-gated calcium ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables immunoglobulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables myosin V binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in behavioral response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to L-glutamate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amine stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ammonium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to brain-derived neurotrophic factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to dsRNA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in conditioned place preference IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ionotropic glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term synaptic depression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of locomotion involved in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of receptor recycling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to fungicide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lithium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to psychosocial stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to sucrose IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in spinal cord development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of AMPA glutamate receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in axonal spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic spine membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane TAS
    Traceable Author Statement
    more info
     
    located_in excitatory synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perisynaptic space IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic density, intracellular component IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in proximal dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glutamate receptor 1
    Names
    AMPA 1
    AMPA receptor subunit GluA1
    AMPA-selective glutamate receptor 1
    gluR-1
    gluR-A
    gluR-K1
    glutamate receptor, ionotropic, AMPA 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047078.1 RefSeqGene

      Range
      5975..329174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000827.4NP_000818.2  glutamate receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000818.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AB209094, AK310189, AL120214, DC335107, M81886, X58633
      Consensus CDS
      CCDS4322.1
      UniProtKB/Swiss-Prot
      B7Z2S0, B7Z2W8, B7Z3F6, B7Z9G9, D3DQI4, E7ESV8, P42261, Q2NKM6
      UniProtKB/TrEMBL
      A8K0K0
      Related
      ENSP00000285900.4, ENST00000285900.10
      Conserved Domains (2) summary
      cd13729
      Location:406787
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06390
      Location:26392
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    2. NM_001114183.2NP_001107655.1  glutamate receptor 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001107655.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a different coding exon in the 3' region, as compared to variant 1. The resulting isoform (2) is the same length but has a different internal segment, as compared to isoform 1.
      Source sequence(s)
      AB209094, AL120214, DC335107, M64752
      Consensus CDS
      CCDS47318.1
      UniProtKB/TrEMBL
      A8K0K0
      Related
      ENSP00000339343.5, ENST00000340592.10
      Conserved Domains (2) summary
      cd13729
      Location:406787
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06390
      Location:26392
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    3. NM_001258019.2NP_001244948.1  glutamate receptor 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001244948.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AB209094, AK295827, AL120214
      Consensus CDS
      CCDS58986.1
      UniProtKB/TrEMBL
      A8K0K0
      Related
      ENSP00000427920.1, ENST00000518142.5
      Conserved Domains (2) summary
      cd13729
      Location:326707
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cl10011
      Location:26312
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    4. NM_001258020.2NP_001244949.1  glutamate receptor 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and has an alternate in-frame exon in place of another exon of the same size. The resulting isoform (4) is shorter at the N-terminus and has a different sequence (but same length) segment in the C-terminus compared to isoform 1.
      Source sequence(s)
      AB209094, AL120214, DC335107
      UniProtKB/TrEMBL
      Q59GL5
      Conserved Domains (4) summary
      cd13729
      Location:311692
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:443722
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:1277
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:1294
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    5. NM_001258021.2NP_001244950.1  glutamate receptor 1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate exon in place of the 5'-most exon of variant 1. The resulting isoform (5) has a longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AB209094, AK295184, AK295827, AK315934, AL120214
      Consensus CDS
      CCDS58987.1
      UniProtKB/TrEMBL
      A8K0K0
      Related
      ENSP00000428994.1, ENST00000518783.1
      Conserved Domains (4) summary
      cd06390
      Location:36399
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
      cd13729
      Location:416797
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:548827
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:47382
      ANF_receptor; Receptor family ligand binding region
    6. NM_001258022.2NP_001244951.1  glutamate receptor 1 isoform 6

      See identical proteins and their annotated locations for NP_001244951.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has an alternate exon in place of the 5'-most exon of variant 1 and has an alternate in-frame exon in place of another exon of the same size. The resulting isoform (6) has a longer and distinct N-terminus and has a different sequence (but same length) segment in the C-terminus compared to isoform 1.
      Source sequence(s)
      AB209094, AK295184, AK315934, AL120214
      Consensus CDS
      CCDS58988.1
      UniProtKB/TrEMBL
      A8K0K0
      Related
      ENSP00000415569.2, ENST00000448073.8
      Conserved Domains (4) summary
      cd06390
      Location:36399
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
      cd13729
      Location:416797
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:548827
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:47382
      ANF_receptor; Receptor family ligand binding region
    7. NM_001258023.1NP_001244952.1  glutamate receptor 1 isoform 7

      See identical proteins and their annotated locations for NP_001244952.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has an alternate exon in place of the 5'-most exon of variant 1. The resulting isoform (7) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AB209094, AK295039, AL120214
      Consensus CDS
      CCDS58989.1
      UniProtKB/TrEMBL
      Q59GL5
      Related
      ENSP00000427864.2, ENST00000521843.6
      Conserved Domains (2) summary
      cd13729
      Location:337718
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cl10011
      Location:1323
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    8. NM_001364165.2NP_001351094.1  glutamate receptor 1 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC010613, AC091960, AC091962
      UniProtKB/TrEMBL
      A8K0K0
      Conserved Domains (2) summary
      cd13729
      Location:350731
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cl10011
      Location:26336
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    9. NM_001364166.2NP_001351095.1  glutamate receptor 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC010613, AC091960, AC091962
      UniProtKB/TrEMBL
      A0A9L9PXG3, A8K0K0
      Related
      ENSP00000516521.1, ENST00000706734.1
      Conserved Domains (2) summary
      cd06390
      Location:35398
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
      cd13729
      Location:415796
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    10. NM_001364167.2NP_001351096.1  glutamate receptor 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC010613, AC091960, AC091962
      UniProtKB/TrEMBL
      Q59GL5
      Conserved Domains (2) summary
      cd13729
      Location:337718
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cl10011
      Location:1323
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    RNA

    1. NR_047578.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate 5' exon and an alternate 3' exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore thought to be non-protein coding.
      Source sequence(s)
      AB209094, AC091960, AK294011, AL120214
    2. NR_157093.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010613, AC091960, AC091962

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      153489615..153813869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417128.1XP_047273084.1  glutamate receptor 1 isoform X1

      UniProtKB/TrEMBL
      A8K0K0
    2. XM_017009392.2XP_016864881.1  glutamate receptor 1 isoform X2

      UniProtKB/TrEMBL
      B7Z1W1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      154022776..154347051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352463.1XP_054208438.1  glutamate receptor 1 isoform X1

      UniProtKB/TrEMBL
      A8K0K0
    2. XM_054352464.1XP_054208439.1  glutamate receptor 1 isoform X2

      UniProtKB/TrEMBL
      B7Z1W1