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    GPX5 glutathione peroxidase 5 [ Homo sapiens (human) ]

    Gene ID: 2880, updated on 12-Oct-2019

    Summary

    Official Symbol
    GPX5provided by HGNC
    Official Full Name
    glutathione peroxidase 5provided by HGNC
    Primary source
    HGNC:HGNC:4557
    See related
    Ensembl:ENSG00000224586 MIM:603435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EGLP; GPx-5; GSHPx-5; HEL-S-75p
    Summary
    This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
    Expression
    Restricted expression toward testis (RPKM 1.2) See more
    Orthologs

    Genomic context

    See GPX5 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (28525881..28534955)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28493789..28502728)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tRNA-Thr (anticodon CGT) 1-1 Neighboring gene glutathione peroxidase 6 Neighboring gene tRNA-Ile (anticodon TAT) 3-1 Neighboring gene uncharacterized LOC107986586 Neighboring gene tRNA-Arg (anticodon TCG) 5-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat causes a greater than 50% decrease in intracellular reduced glutathione (GSH), leading to the extracellular appearance of acidic FGF-1, an effect that is partially mediated through modulation of GSH biosynthetic enzymes PubMed
    tat Expression of HIV-1 Tat in HeLa cells downregulates cytoplasmic glutathione peroxidase while upregulating phospholipid hydroperoxide glutathione peroxidase, thereby deregulating intracellular oxidant/antioxidant balance and amplifying UV sensitivity PubMed
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates expression of six genes, APOE, CCL5, DGKK, GPX5, NOS2, and PXDNL PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    selenium binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidative stress TAS
    Traceable Author Statement
    more info
     
    hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    epididymal secretory glutathione peroxidase
    Names
    epididymal androgen-related protein
    epididymis secretory sperm binding protein Li 75p
    epididymis-specific glutathione peroxidase-like protein
    NP_001500.1
    NP_003987.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047054.1 RefSeqGene

      Range
      4870..13944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001509.3NP_001500.1  epididymal secretory glutathione peroxidase isoform 1 precursor

      See identical proteins and their annotated locations for NP_001500.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL049543
      Consensus CDS
      CCDS4652.1
      UniProtKB/Swiss-Prot
      O75715
      UniProtKB/TrEMBL
      V9HWN8
      Related
      ENSP00000392398.2, ENST00000412168.6
      Conserved Domains (1) summary
      cd00340
      Location:39211
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
    2. NM_003996.3NP_003987.2  epididymal secretory glutathione peroxidase isoform 2 precursor

      See identical proteins and their annotated locations for NP_003987.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal coding exon, which results in a frame-shift, compared to variant 1. The encoded isoform (2) is shorter, with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AJ005277, AL049543, BC128159, BX103177, DB336279
      Consensus CDS
      CCDS4653.1
      UniProtKB/Swiss-Prot
      O75715
      Related
      ENSP00000419935.1, ENST00000469384.1
      Conserved Domains (1) summary
      cl00388
      Location:4090
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RNA

    1. NR_144470.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translation start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      DB024012, FJ460514

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      28525881..28534955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

      Range
      15762..24836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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