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    TRAJ8 T cell receptor alpha joining 8 [ Homo sapiens (human) ]

    Gene ID: 28747, updated on 17-Jun-2019

    Summary

    Official Symbol
    TRAJ8provided by HGNC
    Official Full Name
    T cell receptor alpha joining 8provided by HGNC
    Primary source
    HGNC:HGNC:12096
    See related
    IMGT/GENE-DB:TRAJ8
    Gene type
    other
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]
    Annotation information
    Annotation category: partial on reference assembly

    Genomic context

    See TRAJ8 in Genome Data Viewer
    Location:
    14q11.2
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (22536145..22536204)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23005092..23005151)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene T cell receptor alpha locus Neighboring gene T cell receptor alpha joining 10 Neighboring gene T cell receptor alpha joining 9 Neighboring gene T cell receptor alpha joining 7 Neighboring gene T cell receptor alpha joining 6

    Genomic regions, transcripts, and products

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_001332.3 

      Range
      914242..914301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

      Range
      22536145..22536204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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