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    Flnb filamin, beta [ Mus musculus (house mouse) ]

    Gene ID: 286940, updated on 23-Jun-2021

    Summary

    Official Symbol
    Flnbprovided by MGI
    Official Full Name
    filamin, betaprovided by MGI
    Primary source
    MGI:MGI:2446089
    See related
    Ensembl:ENSMUSG00000025278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fln-b; AL024016
    Expression
    Ubiquitous expression in colon adult (RPKM 35.6), placenta adult (RPKM 32.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Flnb in Genome Data Viewer
    Location:
    14; 14 A1
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (14518185..14651852, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (7817921..7951588)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (8650471..8784102)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene deoxyribonuclease 1-like 3 Neighboring gene predicted gene 45521 Neighboring gene predicted gene 8396 Neighboring gene predicted gene 10044

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    filamin-B
    Names
    ABP-280-like protein
    actin binding protein 278
    actin-binding-like protein
    beta-filamin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081427.1NP_001074896.1  filamin-B isoform a

      See identical proteins and their annotated locations for NP_001074896.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). This gene lacks full-length transcript support, and therefore the exon combination of this variant is inferred based on tiled partial transcripts and full-length orthologous alignments, e.g., human AF043045.1.
      Source sequence(s)
      AA272439, AC140322, AK050046, BG076906, BP753071, BP753829, BP765788, BU055777, BU703688, BY101832, CA749811, CB290081, CD546916, CD549389, CD555839, CF165547, CF166040, CF536812, CF898917, CJ112968, CN534523, CV558093, DV653022, DV653075
      Consensus CDS
      CCDS70540.1
      UniProtKB/Swiss-Prot
      Q80X90
      Related
      ENSMUSP00000052020.9, ENSMUST00000052678.9
      Conserved Domains (4) summary
      smart00557
      Location:14211514
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00014
      Location:17121
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00630
      Location:14181508
      Filamin; Filamin/ABP280 repeat
      cl23780
      Location:17181791
      PepSY_TM; PepSY-associated TM region
    2. NM_134080.1NP_598841.1  filamin-B isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. This gene lacks full-length transcript support, and therefore the exon combination of this variant is inferred based on tiled partial transcripts and full-length orthologous alignments, e.g., human AB191258.1.
      Source sequence(s)
      AC140322, AK050046, BG076906, BM949278, BM950536, BP753072, BP765788, BU055777, BU703688, BY101832, CA537344, CB194973, CB290081, CD546916, CD549389, CD555839, CF165547, CF166040, CF172628, CF551577, CF736029, CJ112968, CN534523, CV558093
      Conserved Domains (3) summary
      smart00557
      Location:14211514
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00014
      Location:17121
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00630
      Location:14181508
      Filamin; Filamin/ABP280 repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      14518185..14651852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518050.2XP_006518113.1  filamin-B isoform X1

      See identical proteins and their annotated locations for XP_006518113.1

      Conserved Domains (2) summary
      smart00557
      Location:14211514
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:14240
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
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