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    FFAR3 free fatty acid receptor 3 [ Homo sapiens (human) ]

    Gene ID: 2865, updated on 6-Jun-2024

    Summary

    Official Symbol
    FFAR3provided by HGNC
    Official Full Name
    free fatty acid receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:4499
    See related
    Ensembl:ENSG00000185897 MIM:603821; AllianceGenome:HGNC:4499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FFA3R; GPR41; GPR42
    Summary
    Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and cellular response to fatty acid. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in appendix (RPKM 1.2), fat (RPKM 0.6) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FFAR3 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35358151..35360489)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37902884..37905223)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35849362..35851391)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CD22 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14475 Neighboring gene MPRA-validated peak3448 silencer Neighboring gene microRNA 5196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35843089-35843955 Neighboring gene free fatty acid receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35850683-35851210 Neighboring gene G protein-coupled receptor 42 Neighboring gene CRISPRi-validated cis-regulatory element chr19.3689 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51280 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to fatty acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mucosal immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of acute inflammatory response to non-antigenic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of chemokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytokine production involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of hormone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of norepinephrine secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of peptide hormone secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    free fatty acid receptor 3
    Names
    G-protein coupled receptor 41

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005304.5NP_005295.1  free fatty acid receptor 3

      See identical proteins and their annotated locations for NP_005295.1

      Status: VALIDATED

      Source sequence(s)
      AC002511, BC035657, DR004234
      Consensus CDS
      CCDS12459.1
      UniProtKB/Swiss-Prot
      B2RWM8, O14843, Q14CM7
      UniProtKB/TrEMBL
      A0A0K0PUV2, A0A0K0PUW4, A0A0K0PUW7, A0A0K0PW26, B0M0K0
      Related
      ENSP00000328230.3, ENST00000327809.5
      Conserved Domains (1) summary
      cd15170
      Location:15289
      7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35358151..35360489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526858.3XP_011525160.1  free fatty acid receptor 3 isoform X1

      UniProtKB/TrEMBL
      A0A0K0PUV2, A0A0K0PUW4, A0A0K0PW26, B0M0K0
      Conserved Domains (1) summary
      pfam00001
      Location:69313
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      37902884..37905223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320733.1XP_054176708.1  free fatty acid receptor 3 isoform X1

      UniProtKB/TrEMBL
      A0A0K0PUV2