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    ATP11C ATPase phospholipid transporting 11C [ Homo sapiens (human) ]

    Gene ID: 286410, updated on 8-Jul-2021

    Summary

    Official Symbol
    ATP11Cprovided by HGNC
    Official Full Name
    ATPase phospholipid transporting 11Cprovided by HGNC
    Primary source
    HGNC:HGNC:13554
    See related
    Ensembl:ENSG00000101974 MIM:300516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATPIG; ATPIQ; HACXL
    Expression
    Ubiquitous expression in liver (RPKM 9.4), urinary bladder (RPKM 5.9) and 24 other tissues See more
    Orthologs
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    Genomic context

    See ATP11C in Genome Data Viewer
    Location:
    Xq27.1
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (139726346..139933083, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (138808507..139015212, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MCF.2 cell line derived transforming sequence Neighboring gene brain cytoplasmic RNA 1, pseudogene 1 Neighboring gene RNA, U6atac small nuclear 23, pseudogene Neighboring gene microRNA 505 Neighboring gene chromosome X open reading frame 66 Neighboring gene uncharacterized LOC728660

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATPase-coupled intramembrane lipid transporter activity TAS
    Traceable Author Statement
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylethanolamine flippase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine flippase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in aminophospholipid translocation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phospholipid translocation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    phospholipid-transporting ATPase IG
    Names
    ATPase, class VI, type 11C
    P4-ATPase flippase complex alpha subunit ATP11C
    probable phospholipid-transporting ATPase IG
    NP_001010986.2
    NP_001340739.2
    NP_001340740.2
    NP_001340741.2
    NP_775965.3
    XP_016884928.1
    XP_016884929.1
    XP_016884930.1
    XP_016884931.1
    XP_016884932.1
    XP_016884934.1
    XP_016884935.1
    XP_016884937.1
    XP_016884938.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016550.2 RefSeqGene

      Range
      105796..211738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001010986.3NP_001010986.2  phospholipid-transporting ATPase IG isoform b

      Status: VALIDATED

      Source sequence(s)
      AL161777, AL356785
      Consensus CDS
      CCDS35410.1
      Related
      ENSP00000355165.2, ENST00000361648.6
      Conserved Domains (2) summary
      cd02073
      Location:45977
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:8651092
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    2. NM_001353810.2NP_001340739.2  phospholipid-transporting ATPase IG isoform c

      Status: VALIDATED

      Source sequence(s)
      AL161777, AL356785, AL590077
      Related
      ENSP00000359588.1, ENST00000370557.5
      Conserved Domains (2) summary
      cd02073
      Location:42974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:8621089
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    3. NM_001353811.2NP_001340740.2  phospholipid-transporting ATPase IG isoform d

      Status: VALIDATED

      Source sequence(s)
      AL161777, AL356785, AL590077
      Conserved Domains (2) summary
      cd02073
      Location:42974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:8621089
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    4. NM_001353812.2NP_001340741.2  phospholipid-transporting ATPase IG isoform e

      Status: VALIDATED

      Source sequence(s)
      AL161777, AL356785, AL590077
      Related
      ENSP00000507250.1, ENST00000682941.1
      Conserved Domains (2) summary
      cd02073
      Location:42974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:8621089
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    5. NM_173694.5NP_775965.3  phospholipid-transporting ATPase IG isoform a

      Status: VALIDATED

      Source sequence(s)
      AL161777, AL356785
      Consensus CDS
      CCDS14668.1
      Related
      ENSP00000332756.3, ENST00000327569.7
      Conserved Domains (2) summary
      cd02073
      Location:45977
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam16212
      Location:8651092
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      139726346..139933083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029449.1XP_016884938.1  phospholipid-transporting ATPase IG isoform X8

      Conserved Domains (4) summary
      pfam13246
      Location:203307
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16212
      Location:597824
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl14615
      Location:333409
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl21460
      Location:546575
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    2. XM_017029448.1XP_016884937.1  phospholipid-transporting ATPase IG isoform X7

    3. XM_017029440.2XP_016884929.1  phospholipid-transporting ATPase IG isoform X2

    4. XM_017029441.1XP_016884930.1  phospholipid-transporting ATPase IG isoform X2

    5. XM_017029442.1XP_016884931.1  phospholipid-transporting ATPase IG isoform X3

    6. XM_017029446.2XP_016884935.1  phospholipid-transporting ATPase IG isoform X6

    7. XM_017029439.2XP_016884928.1  phospholipid-transporting ATPase IG isoform X1

    8. XM_017029443.2XP_016884932.1  phospholipid-transporting ATPase IG isoform X4

    9. XM_017029445.2XP_016884934.1  phospholipid-transporting ATPase IG isoform X5

    RNA

    1. XR_001755684.2 RNA Sequence

    2. XR_001755685.1 RNA Sequence

    3. XR_002958774.1 RNA Sequence

    4. XR_001755683.2 RNA Sequence

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