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    ZNF707 zinc finger protein 707 [ Homo sapiens (human) ]

    Gene ID: 286075, updated on 5-Mar-2024

    Summary

    Official Symbol
    ZNF707provided by HGNC
    Official Full Name
    zinc finger protein 707provided by HGNC
    Primary source
    HGNC:HGNC:27815
    See related
    Ensembl:ENSG00000181135 AllianceGenome:HGNC:27815
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 4.1), spleen (RPKM 3.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF707 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143684479..143695385)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144840870..144851771)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144766649..144777555)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 623 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC105375799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144751216-144751716 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144751717-144752217 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:144764224-144764449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144781964-144782464 Neighboring gene long intergenic non-protein coding RNA 2878 Neighboring gene uncharacterized LOC101928160 Neighboring gene coiled-coil domain containing 166

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100598.2NP_001094068.1  zinc finger protein 707 isoform a

      See identical proteins and their annotated locations for NP_001094068.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AK001126, AK055263, AW294133, BC014894, CV023324, DA007942, DB249556
      Consensus CDS
      CCDS47932.1
      UniProtKB/Swiss-Prot
      A8K317, B3KNY1, D3DWK7, Q96C28
      Related
      ENSP00000351482.4, ENST00000358656.9
      Conserved Domains (6) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:187366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262282
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:218242
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001100599.2NP_001094069.1  zinc finger protein 707 isoform a

      See identical proteins and their annotated locations for NP_001094069.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AK001126, AK055263, AW294133, BC014894, CV023324, DA917297, DB249556
      Consensus CDS
      CCDS47932.1
      UniProtKB/Swiss-Prot
      A8K317, B3KNY1, D3DWK7, Q96C28
      Conserved Domains (6) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:187366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262282
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:218242
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001288805.2NP_001275734.1  zinc finger protein 707 isoform a

      See identical proteins and their annotated locations for NP_001275734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes isoform a. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AC105219, AK095138, AK290432, AW294133, DB249556
      Consensus CDS
      CCDS47932.1
      UniProtKB/Swiss-Prot
      A8K317, B3KNY1, D3DWK7, Q96C28
      Related
      ENSP00000436212.1, ENST00000532205.5
      Conserved Domains (6) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:187366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262282
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:218242
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001288806.2NP_001275735.1  zinc finger protein 707 isoform a

      See identical proteins and their annotated locations for NP_001275735.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AC105219, AK290432, AW294133, DA188478, DA990503
      Consensus CDS
      CCDS47932.1
      UniProtKB/Swiss-Prot
      A8K317, B3KNY1, D3DWK7, Q96C28
      Conserved Domains (6) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:187366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262282
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:218242
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001288807.2NP_001275736.1  zinc finger protein 707 isoform b

      See identical proteins and their annotated locations for NP_001275736.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon in an alternate exon, compared to variant 4. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC105219, AK290432, AW294133, DA957023, DB249556
      UniProtKB/Swiss-Prot
      Q96C28
      Conserved Domains (4) summary
      COG5048
      Location:95262
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:189209
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:187209
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145169
      zf-H2C2_2; Zinc-finger double domain
    6. NM_001288808.2NP_001275737.1  zinc finger protein 707 isoform c

      See identical proteins and their annotated locations for NP_001275737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. This results in a shorter protein (isoform c), compared to isoform a. Variants 7 and 8 encode the same protein (isoform c).
      Source sequence(s)
      AC105219, AK290432, AW294133, DA188478, DB106612
      UniProtKB/Swiss-Prot
      Q96C28
      Conserved Domains (5) summary
      smart00349
      Location:132
      KRAB; krueppel associated box
      COG5048
      Location:151330
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226246
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:224246
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:182206
      zf-H2C2_2; Zinc-finger double domain
    7. NM_001288809.2NP_001275738.1  zinc finger protein 707 isoform c

      See identical proteins and their annotated locations for NP_001275738.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. This results in a shorter protein (isoform c), compared to isoform a. Variants 7 and 8 encode the same protein (isoform c).
      Source sequence(s)
      AC105219, AK001126, AK290432, AW294133, DA188478, DB125792
      UniProtKB/Swiss-Prot
      Q96C28
      Conserved Domains (5) summary
      smart00349
      Location:132
      KRAB; krueppel associated box
      COG5048
      Location:151330
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226246
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:224246
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:182206
      zf-H2C2_2; Zinc-finger double domain
    8. NM_173831.4NP_776192.2  zinc finger protein 707 isoform a

      See identical proteins and their annotated locations for NP_776192.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AK001126, AK055263, AW294133, BC014894, CV023324, DB249556
      Consensus CDS
      CCDS47932.1
      UniProtKB/Swiss-Prot
      A8K317, B3KNY1, D3DWK7, Q96C28
      Related
      ENSP00000436250.1, ENST00000532158.5
      Conserved Domains (6) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:187366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262282
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:218242
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_110190.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks multiple 5' exons and uses an alternate 3' splice site, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC105219, AK001126, AK290432, AW294133, DB249556
      Related
      ENST00000533031.5
    2. NR_110191.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in its 5' exon structure and uses an alternate 3' splice site, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC105219, AK290432, AW294133, DB099015
    3. NR_110192.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in its 5' exon structure and uses an alternate 3' splice sites, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC105219, AK001126, AK290432, AW294133, DA188478
    4. NR_110193.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in its 5' exon structure and uses an alternate 3' splice site, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC105219, AK001126, AK290432, AW294133, DA555314

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      143684479..143695385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187571.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      161526..172432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      144840870..144851771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)