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    RNF180 ring finger protein 180 [ Homo sapiens (human) ]

    Gene ID: 285671, updated on 17-Jun-2024

    Summary

    Official Symbol
    RNF180provided by HGNC
    Official Full Name
    ring finger protein 180provided by HGNC
    Primary source
    HGNC:HGNC:27752
    See related
    Ensembl:ENSG00000164197 MIM:616015; AllianceGenome:HGNC:27752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RINES
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in norepinephrine metabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and serotonin metabolic process. Predicted to act upstream of or within several processes, including adult behavior; positive regulation of protein ubiquitination; and protein polyubiquitination. Predicted to be located in nuclear envelope. Predicted to be integral component of membrane. Predicted to be intrinsic component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thyroid (RPKM 3.9), brain (RPKM 2.6) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RNF180 in Genome Data Viewer
    Location:
    5q12.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (64165351..64372869)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (64985393..65192972)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (63461670..63668696)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378999 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:63256149-63256370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:63257009-63257986 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:63315837-63316027 Neighboring gene 5-hydroxytryptamine receptor 1A Neighboring gene Sharpr-MPRA regulatory region 1263 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:63702820-63703320 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:63703321-63703821 Neighboring gene regulator of G protein signaling 7 binding protein Neighboring gene RNA, 7SL, cytoplasmic 169, pseudogene Neighboring gene RNA, U6 small nuclear 294, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC120326, MGC120328

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in adult behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in norepinephrine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in serotonin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF180
    Names
    RING-type E3 ubiquitin transferase RNF180
    NP_001107033.1
    NP_001310220.1
    NP_001310221.1
    NP_848627.1
    XP_016864872.1
    XP_016864875.1
    XP_016864876.1
    XP_016864877.1
    XP_016864878.1
    XP_047273072.1
    XP_047273074.1
    XP_047273075.1
    XP_047273076.1
    XP_047273077.1
    XP_047273078.1
    XP_054208421.1
    XP_054208422.1
    XP_054208423.1
    XP_054208424.1
    XP_054208425.1
    XP_054208426.1
    XP_054208427.1
    XP_054208428.1
    XP_054208429.1
    XP_054208430.1
    XP_054208431.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113561.2NP_001107033.1  E3 ubiquitin-protein ligase RNF180 isoform 1

      See identical proteins and their annotated locations for NP_001107033.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL832580, DA183707, DA809479
      Consensus CDS
      CCDS47219.1
      UniProtKB/Swiss-Prot
      Q0JSU3, Q495A8, Q86T96, Q8NBD1
      Related
      ENSP00000373752.4, ENST00000389100.9
      Conserved Domains (1) summary
      cd16554
      Location:431474
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins
    2. NM_001323291.1NP_001310220.1  E3 ubiquitin-protein ligase RNF180 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC092360, AK090756, BC101279, DA183707
      UniProtKB/TrEMBL
      D6RE88
    3. NM_001323292.2NP_001310221.1  E3 ubiquitin-protein ligase RNF180 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC016623, AL832580, BC101397, DA183707, DA809479
      UniProtKB/Swiss-Prot
      Q86T96
    4. NM_178532.4NP_848627.1  E3 ubiquitin-protein ligase RNF180 isoform 2

      See identical proteins and their annotated locations for NP_848627.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' coding exons and differs in the 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC092360, AK090756, BC101277, DA183707
      Consensus CDS
      CCDS34169.1
      UniProtKB/Swiss-Prot
      Q86T96
      Related
      ENSP00000296615.6, ENST00000296615.10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      64165351..64372869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417118.1XP_047273074.1  E3 ubiquitin-protein ligase RNF180 isoform X1

    2. XM_047417120.1XP_047273076.1  E3 ubiquitin-protein ligase RNF180 isoform X5

      UniProtKB/Swiss-Prot
      Q0JSU3, Q495A8, Q86T96, Q8NBD1
    3. XM_017009388.2XP_016864877.1  E3 ubiquitin-protein ligase RNF180 isoform X1

    4. XM_047417119.1XP_047273075.1  E3 ubiquitin-protein ligase RNF180 isoform X5

      UniProtKB/Swiss-Prot
      Q0JSU3, Q495A8, Q86T96, Q8NBD1
    5. XM_017009383.2XP_016864872.1  E3 ubiquitin-protein ligase RNF180 isoform X1

    6. XM_017009386.3XP_016864875.1  E3 ubiquitin-protein ligase RNF180 isoform X2

    7. XM_047417116.1XP_047273072.1  E3 ubiquitin-protein ligase RNF180 isoform X3

    8. XM_017009387.1XP_016864876.1  E3 ubiquitin-protein ligase RNF180 isoform X4

    9. XM_047417121.1XP_047273077.1  E3 ubiquitin-protein ligase RNF180 isoform X5

      UniProtKB/Swiss-Prot
      Q0JSU3, Q495A8, Q86T96, Q8NBD1
    10. XM_047417122.1XP_047273078.1  E3 ubiquitin-protein ligase RNF180 isoform X3

    11. XM_017009389.2XP_016864878.1  E3 ubiquitin-protein ligase RNF180 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      64985393..65192972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352453.1XP_054208428.1  E3 ubiquitin-protein ligase RNF180 isoform X5

      UniProtKB/Swiss-Prot
      Q0JSU3, Q495A8, Q86T96, Q8NBD1
    2. XM_054352450.1XP_054208425.1  E3 ubiquitin-protein ligase RNF180 isoform X1

    3. XM_054352451.1XP_054208426.1  E3 ubiquitin-protein ligase RNF180 isoform X1

    4. XM_054352454.1XP_054208429.1  E3 ubiquitin-protein ligase RNF180 isoform X5

      UniProtKB/Swiss-Prot
      Q0JSU3, Q495A8, Q86T96, Q8NBD1
    5. XM_054352446.1XP_054208421.1  E3 ubiquitin-protein ligase RNF180 isoform X1

    6. XM_054352447.1XP_054208422.1  E3 ubiquitin-protein ligase RNF180 isoform X2

    7. XM_054352448.1XP_054208423.1  E3 ubiquitin-protein ligase RNF180 isoform X3

    8. XM_054352449.1XP_054208424.1  E3 ubiquitin-protein ligase RNF180 isoform X4

    9. XM_054352455.1XP_054208430.1  E3 ubiquitin-protein ligase RNF180 isoform X5

      UniProtKB/Swiss-Prot
      Q0JSU3, Q495A8, Q86T96, Q8NBD1
    10. XM_054352456.1XP_054208431.1  E3 ubiquitin-protein ligase RNF180 isoform X3

    11. XM_054352452.1XP_054208427.1  E3 ubiquitin-protein ligase RNF180 isoform X1