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    SLC36A3 solute carrier family 36 member 3 [ Homo sapiens (human) ]

    Gene ID: 285641, updated on 17-Jun-2024

    Summary

    Official Symbol
    SLC36A3provided by HGNC
    Official Full Name
    solute carrier family 36 member 3provided by HGNC
    Primary source
    HGNC:HGNC:19659
    See related
    Ensembl:ENSG00000186334 MIM:608332; AllianceGenome:HGNC:19659
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAT3; TRAMD2; tramdorin2
    Summary
    Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transport and proton transmembrane transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 4.0) See more
    Orthologs
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    Genomic context

    See SLC36A3 in Genome Data Viewer
    Location:
    5q33.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (151276358..151303766, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (151815323..151842709, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150655919..150683327, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901115 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23455 Neighboring gene ganglioside GM2 activator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23456 Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 5 Neighboring gene solute carrier family 36 member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:150726633-150727546 Neighboring gene uncharacterized LOC105378234 Neighboring gene solute carrier family 36 member 1 Neighboring gene mediator complex subunit 13 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16658, MGC119638, MGC119639, MGC119641

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-alanine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-proline transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables amino acid:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in L-alanine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proline transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    proton-coupled amino acid transporter 3
    Names
    proton/amino acid transporter 3
    solute carrier family 36 (proton/amino acid symporter), member 3
    tramdorin 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145017.2NP_001138489.1  proton-coupled amino acid transporter 3 isoform 1

      See identical proteins and their annotated locations for NP_001138489.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC008385, BC101092
      Consensus CDS
      CCDS47316.1
      UniProtKB/Swiss-Prot
      Q495N2
      Related
      ENSP00000366942.3, ENST00000377713.3
      Conserved Domains (1) summary
      cl00456
      Location:41492
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. NM_181774.4NP_861439.3  proton-coupled amino acid transporter 3 isoform 2

      See identical proteins and their annotated locations for NP_861439.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has the identical N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC008385, BC101095
      Consensus CDS
      CCDS4314.1
      UniProtKB/Swiss-Prot
      Q495N2, Q495N3, Q6ZMU7, Q6ZRU4, Q7Z6B4
      Related
      ENSP00000334750.3, ENST00000335230.8
      Conserved Domains (1) summary
      cl00456
      Location:41451
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      151276358..151303766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537627.4XP_011535929.1  proton-coupled amino acid transporter 3 isoform X1

      Conserved Domains (1) summary
      cl00456
      Location:41425
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_011537631.3XP_011535933.1  proton-coupled amino acid transporter 3 isoform X2

      See identical proteins and their annotated locations for XP_011535933.1

      Conserved Domains (1) summary
      cl00456
      Location:13336
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. XM_011537630.3XP_011535932.1  proton-coupled amino acid transporter 3 isoform X2

      See identical proteins and their annotated locations for XP_011535932.1

      Conserved Domains (1) summary
      cl00456
      Location:13336
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. XM_011537633.2XP_011535935.1  proton-coupled amino acid transporter 3 isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:42288
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    5. XM_011537634.3XP_011535936.1  proton-coupled amino acid transporter 3 isoform X4

      Conserved Domains (1) summary
      cl00456
      Location:41163
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      151815323..151842709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352441.1XP_054208416.1  proton-coupled amino acid transporter 3 isoform X1

    2. XM_054352443.1XP_054208418.1  proton-coupled amino acid transporter 3 isoform X2

    3. XM_054352442.1XP_054208417.1  proton-coupled amino acid transporter 3 isoform X2

    4. XM_054352444.1XP_054208419.1  proton-coupled amino acid transporter 3 isoform X3

    5. XM_054352445.1XP_054208420.1  proton-coupled amino acid transporter 3 isoform X4