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    GPR33 G protein-coupled receptor 33 [ Homo sapiens (human) ]

    Gene ID: 2856, updated on 4-Jan-2025

    Summary

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    Official Symbol
    GPR33provided by HGNC
    Official Full Name
    G protein-coupled receptor 33provided by HGNC
    Primary source
    HGNC:HGNC:4489
    See related
    Ensembl:ENSG00000214943 MIM:610118; AllianceGenome:HGNC:4489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

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    See GPR33 in Genome Data Viewer
    Location:
    14q12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (31482875..31488039, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (25680197..25685200, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31952081..31957245, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene HEATR5A divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:31925731-31926316 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:31926317-31926902 Neighboring gene uncharacterized LOC105370438 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:31961704-31962903 Neighboring gene D-aminoacyl-tRNA deacylase 2 Neighboring gene ribosomal protein L9 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8236 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:32030779-32031334 Neighboring gene NUBPL divergent transcript Neighboring gene NUBP iron-sulfur cluster assembly factor, mitochondrial Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:32090343-32090842 Neighboring gene MPRA-validated peak2131 silencer Neighboring gene RNA, U6 small nuclear 602, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Involvement of the chemokine-like receptor GPR33 in innate immunity. Bohnekamp J, et al. Biochem Biophys Res Commun, 2010 May 28. PMID 20399748, Free PMC Article
    2. Cloning genes encoding receptors related to chemoattractant receptors. Marchese A, et al. Genomics, 1998 Jun 1. PMID 9653656
    3. The rise and fall of the chemoattractant receptor GPR33. Römpler H, et al. J Biol Chem, 2005 Sep 2. PMID 15987686
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables complement receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 33
    Names
    G protein-coupled receptor 33 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197184.3 → NP_001184113.2  probable G-protein coupled receptor 33

      See identical proteins and their annotated locations for NP_001184113.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, coding) represents the protein coding transcript, encoding Arg (CGA, aa 140) at the polymorphic site instead of the premature translation termination codon (TGA).
      Source sequence(s)
      AL163973, GQ981322, KF459682
      Consensus CDS
      CCDS73628.1
      UniProtKB/Swiss-Prot
      Q49SQ1
      UniProtKB/TrEMBL
      D8VER1
      Related
      ENSP00000421557.1, ENST00000399285.5
      Conserved Domains (1) summary
      pfam00001
      Location:47 → 265
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RNA

    1. NR_036675.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) represents the predominant non-functional allele. It contains a translation termination codon (TGA) at the polymorphic site, resulting in a truncated open reading frame (ORF), compared to the full-length ORF in variant 1, coding.
      Source sequence(s)
      AL163973, GQ981321

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      31482875..31488039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      25680197..25685200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_001132.2: Suppressed sequence

      Description
      NG_001132.2: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q49SQ1.1 GenPept UniProtKB/Swiss-Prot:Q49SQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials