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    DNAJC5G DnaJ heat shock protein family (Hsp40) member C5 gamma [ Homo sapiens (human) ]

    Gene ID: 285126, updated on 3-Apr-2024

    Summary

    Official Symbol
    DNAJC5Gprovided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C5 gammaprovided by HGNC
    Primary source
    HGNC:HGNC:24844
    See related
    Ensembl:ENSG00000163793 MIM:613946; AllianceGenome:HGNC:24844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSP-gamma
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 12.4) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DNAJC5G in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27275433..27281499)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27306154..27323119)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27498301..27504367)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11291 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27454350-27455549 Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27465505-27466704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27472326-27473120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27473121-27473914 Neighboring gene solute carrier family 30 member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11296 Neighboring gene tripartite motif containing 54 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:27524348-27524553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27543343-27543946 Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15498 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27545801-27546773 Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene urocortin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 5G
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
    cysteine string protein-gamma
    gamma-CSP
    gamma-cysteine string protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303127.2NP_001290056.1  dnaJ homolog subfamily C member 5G isoform 1

      See identical proteins and their annotated locations for NP_001290056.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC013413, AK097736, BC035194
      Consensus CDS
      CCDS1744.1
      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
      UniProtKB/TrEMBL
      B5MCA9
      Related
      ENSP00000384305.1, ENST00000402462.5
      Conserved Domains (2) summary
      COG0484
      Location:1398
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:1795
      DnaJ; DnaJ domain
    2. NM_001303128.2NP_001290057.1  dnaJ homolog subfamily C member 5G isoform 2

      See identical proteins and their annotated locations for NP_001290057.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AC013413, AK097736, AK302239, BC035194
      Consensus CDS
      CCDS77397.1
      UniProtKB/Swiss-Prot
      Q8N7S2
      Related
      ENSP00000385533.1, ENST00000406962.1
      Conserved Domains (1) summary
      cl02542
      Location:1741
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    3. NM_173650.3NP_775921.1  dnaJ homolog subfamily C member 5G isoform 1

      See identical proteins and their annotated locations for NP_775921.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC013413, AF368277, AI183575, AK097736, BC035194
      Consensus CDS
      CCDS1744.1
      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
      UniProtKB/TrEMBL
      B5MCA9
      Related
      ENSP00000296097.3, ENST00000296097.8
      Conserved Domains (2) summary
      COG0484
      Location:1398
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:1795
      DnaJ; DnaJ domain

    RNA

    1. NR_130126.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC013413, AK097736, BC035194, DB454465

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      27275433..27281499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003872.3XP_016859361.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
      UniProtKB/TrEMBL
      B5MCA9
      Conserved Domains (2) summary
      COG0484
      Location:1398
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:1795
      DnaJ; DnaJ domain
    2. XM_017003873.3XP_016859362.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
      UniProtKB/TrEMBL
      B5MCA9
      Conserved Domains (2) summary
      COG0484
      Location:1398
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:1795
      DnaJ; DnaJ domain
    3. XM_006711995.4XP_006712058.1  dnaJ homolog subfamily C member 5G isoform X1

      See identical proteins and their annotated locations for XP_006712058.1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
      UniProtKB/TrEMBL
      B5MCA9
      Conserved Domains (2) summary
      COG0484
      Location:1398
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:1795
      DnaJ; DnaJ domain
    4. XM_017003874.3XP_016859363.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
      UniProtKB/TrEMBL
      B5MCA9
      Related
      ENSP00000385829.1, ENST00000404433.5
      Conserved Domains (2) summary
      COG0484
      Location:1398
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:1795
      DnaJ; DnaJ domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      27306154..27323119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341502.1XP_054197477.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
    2. XM_054341505.1XP_054197480.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
    3. XM_054341506.1XP_054197481.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
    4. XM_054341504.1XP_054197479.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
    5. XM_054341503.1XP_054197478.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
    6. XM_054341507.1XP_054197482.1  dnaJ homolog subfamily C member 5G isoform X2