U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ZNF763 zinc finger protein 763 [ Homo sapiens (human) ]

    Gene ID: 284390, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF763provided by HGNC
    Official Full Name
    zinc finger protein 763provided by HGNC
    Primary source
    HGNC:HGNC:27614
    See related
    Ensembl:ENSG00000197054 AllianceGenome:HGNC:27614
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF; ZNF440L
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 2.5), thyroid (RPKM 2.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF763 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11965040..11980617)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12093250..12108811)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12075855..12091432)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 69 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12035565-12036137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10135 Neighboring gene zinc finger protein 700 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:12060504-12060733 Neighboring gene vomeronasal 2 receptor 21 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12074983-12075936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10136 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12098284-12099226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12099227-12100168 Neighboring gene ZNF433 and ZNF878 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14042 Neighboring gene RNA, 5S ribosomal pseudogene 464 Neighboring gene zinc finger protein 433 Neighboring gene RNA, 5S ribosomal pseudogene 465

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: ZNF700

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 763
    Names
    DNA-binding protein
    zinc finger protein 440 like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012753.2NP_001012771.1  zinc finger protein 763 isoform 2

      See identical proteins and their annotated locations for NP_001012771.1

      Status: VALIDATED

      Source sequence(s)
      AC008770, AK092240
      Consensus CDS
      CCDS45982.1
      UniProtKB/Swiss-Prot
      Q0D2J5
      Related
      ENSP00000369774.2, ENST00000343949.9
      Conserved Domains (6) summary
      smart00349
      Location:749
      KRAB; krueppel associated box
      COG5048
      Location:202390
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:233253
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:746
      KRAB; KRAB box
      pfam13465
      Location:332354
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:342383
      DUF45; Protein of unknown function DUF45
    2. NM_001367172.2NP_001354101.1  zinc finger protein 763 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008770, BC105711, DA264374
      Consensus CDS
      CCDS92522.1
      UniProtKB/Swiss-Prot
      B3KRU3, B4DRE7, Q0D2J5
      Related
      ENSP00000402017.1, ENST00000358987.8
      Conserved Domains (3) summary
      COG5048
      Location:199387
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:230250
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:344
      KRAB; KRAB box
    3. NM_001367173.2NP_001354102.1  zinc finger protein 763 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008770
      Conserved Domains (3) summary
      COG5048
      Location:201389
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:232252
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:546
      KRAB; KRAB box
    4. NM_001367174.2NP_001354103.1  zinc finger protein 763 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC008770, BC105711, DA943561
      Conserved Domains (2) summary
      COG5048
      Location:77265
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:108128
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11965040..11980617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      12093250..12108811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)