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    PPP1R37 protein phosphatase 1 regulatory subunit 37 [ Homo sapiens (human) ]

    Gene ID: 284352, updated on 5-Mar-2024

    Summary

    Official Symbol
    PPP1R37provided by HGNC
    Official Full Name
    protein phosphatase 1 regulatory subunit 37provided by HGNC
    Primary source
    HGNC:HGNC:27607
    See related
    Ensembl:ENSG00000104866 AllianceGenome:HGNC:27607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRRC68
    Summary
    Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of catalytic activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney (RPKM 8.3), brain (RPKM 8.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See PPP1R37 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45093179..45147285)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47918310..47972416)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45596437..45650543)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10753 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:45582765-45583532 Neighboring gene zinc finger protein 296 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45584301-45585066 Neighboring gene gem nuclear organelle associated protein 7 Neighboring gene GEMIN7 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45593049-45594044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45594045-45595039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45600806-45601394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45601395-45601984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45603163-45603750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45608463-45609052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45619689-45620344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14785 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45632987-45633488 Neighboring gene Sharpr-MPRA regulatory region 10789 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45638457-45639261 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 3 Neighboring gene MPRA-validated peak3514 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45641146-45641718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45656063-45656688 Neighboring gene uncharacterized LOC105372420 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:45657908-45658134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45658871-45659588 Neighboring gene NTPase KAP family P-loop domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45663890-45664522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14787 Neighboring gene trafficking protein particle complex subunit 6A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45680873-45681816

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1986

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 37
    Names
    leucine rich repeat containing 68
    leucine-rich repeat-containing protein 68

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019121.2NP_061994.1  protein phosphatase 1 regulatory subunit 37

      See identical proteins and their annotated locations for NP_061994.1

      Status: VALIDATED

      Source sequence(s)
      AC005757, AC011489
      Consensus CDS
      CCDS56096.1
      UniProtKB/Swiss-Prot
      B5MDA4, O75864, Q8IWK3, Q8TF16
      Related
      ENSP00000221462.3, ENST00000221462.9
      Conserved Domains (2) summary
      cd00116
      Location:110429
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:141163
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      45093179..45147285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      47918310..47972416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)