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    NEK8 NIMA related kinase 8 [ Homo sapiens (human) ]

    Gene ID: 284086, updated on 11-Jun-2021

    Summary

    Official Symbol
    NEK8provided by HGNC
    Official Full Name
    NIMA related kinase 8provided by HGNC
    Primary source
    HGNC:HGNC:13387
    See related
    Ensembl:ENSG00000160602 MIM:609799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JCK; NPHP9; RHPD2; NEK12A
    Summary
    This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.8), lymph node (RPKM 2.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See NEK8 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28728788..28743455)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27055806..27070473)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a Neighboring gene small nucleolar RNA, C/D box 4B Neighboring gene TLC domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 11843 Neighboring gene TNF receptor associated factor 4 Neighboring gene family with sequence similarity 222 member B Neighboring gene ribosomal protein L31 pseudogene 58

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC138445

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in determination of left/right symmetry IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of hippo signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in ciliary base IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary inversin compartment IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek8
    Names
    NIMA (never in mitosis gene a)- related kinase 8
    NIMA-family kinase NEK8
    NIMA-related kinase 12a
    nephrocystin 9
    never in mitosis A-related kinase 8
    nimA-related protein kinase 8
    nima-related protein kinase 12a
    serine/thrionine-protein kinase NEK8
    NP_835464.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012263.1 RefSeqGene

      Range
      4975..19642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_178170.3NP_835464.1  serine/threonine-protein kinase Nek8

      See identical proteins and their annotated locations for NP_835464.1

      Status: REVIEWED

      Source sequence(s)
      AC010761, AY242354, CV811826
      Consensus CDS
      CCDS32597.1
      UniProtKB/Swiss-Prot
      Q86SG6
      Related
      ENSP00000268766.6, ENST00000268766.11
      Conserved Domains (2) summary
      cd08220
      Location:3258
      STKc_Nek8; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8
      cl27697
      Location:276657
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      28728788..28743455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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