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    INO80E INO80 complex subunit E [ Homo sapiens (human) ]

    Gene ID: 283899, updated on 3-Apr-2024

    Summary

    Official Symbol
    INO80Eprovided by HGNC
    Official Full Name
    INO80 complex subunit Eprovided by HGNC
    Primary source
    HGNC:HGNC:26905
    See related
    Ensembl:ENSG00000169592 AllianceGenome:HGNC:26905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCDC95
    Summary
    Predicted to be involved in DNA recombination; DNA repair; and chromatin remodeling. Located in nucleolus and nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 18.0), spleen (RPKM 15.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    16p11.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (29996241..30005791)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30278881..30288431)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30007562..30017112)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:29985672-29986443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29987081-29987582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:29987583-29988082 Neighboring gene TAO kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30002153-30002740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30004428-30004928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30004929-30005429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10687 Neighboring gene HIRA interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30015046-30015830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7347 Neighboring gene double C2 domain alpha Neighboring gene chromosome 16 open reading frame 92 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30039801-30040645 Neighboring gene TLC domain containing 3B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7348 Neighboring gene MPRA-validated peak2562 silencer Neighboring gene uncharaterized LOC112694756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30064875-30065853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30065854-30066831 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30076132-30076912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7350 Neighboring gene aldolase, fructose-bisphosphate A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of INO80 complex subunit E (INO80E) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ00079, FLJ90652

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    INO80 complex subunit E
    Names
    coiled-coil domain containing 95
    coiled-coil domain-containing protein 95

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304562.2NP_001291491.1  INO80 complex subunit E isoform 2

      See identical proteins and their annotated locations for NP_001291491.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC093512, AL525020, BC047712, BI093312
      Consensus CDS
      CCDS76853.1
      UniProtKB/TrEMBL
      H3BNM4, J3KNE2
      Related
      ENSP00000303977.7, ENST00000304516.11
      Conserved Domains (1) summary
      pfam08537
      Location:1265
      NBP1; Fungal Nap binding protein NBP1
    2. NM_001304563.2NP_001291492.1  INO80 complex subunit E isoform 3

      See identical proteins and their annotated locations for NP_001291492.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 3' end compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC093512, AL525020, BC047712, BU528528
      UniProtKB/TrEMBL
      I3NI13
    3. NM_173618.3NP_775889.1  INO80 complex subunit E isoform 1

      See identical proteins and their annotated locations for NP_775889.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC093512, AK075133, BC047712
      Consensus CDS
      CCDS10665.1
      UniProtKB/Swiss-Prot
      Q6Y2K3, Q8NBZ0
      UniProtKB/TrEMBL
      H3BNM4
      Related
      ENSP00000457016.1, ENST00000563197.6

    RNA

    1. NR_130786.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction at the 5' end of an internal exon and contains an alternate exon in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093512, AL525020, BC047712, BM924992, BX356644
    2. NR_130787.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction at the 5' end of an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093512, AL525020, BC047712, BM924992
    3. NR_134855.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains four alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL525020, BC035693
      Related
      ENST00000567987.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      29996241..30005791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545812.4XP_011544114.1  INO80 complex subunit E isoform X11

      UniProtKB/TrEMBL
      I3NI13
    2. XM_047433982.1XP_047289938.1  INO80 complex subunit E isoform X2

    3. XM_047433983.1XP_047289939.1  INO80 complex subunit E isoform X3

    4. XM_047433984.1XP_047289940.1  INO80 complex subunit E isoform X4

    5. XM_047433985.1XP_047289941.1  INO80 complex subunit E isoform X5

    6. XM_047433987.1XP_047289943.1  INO80 complex subunit E isoform X8

    7. XM_011545809.4XP_011544111.1  INO80 complex subunit E isoform X7

      UniProtKB/TrEMBL
      I3NI13
    8. XM_024450238.2XP_024306006.1  INO80 complex subunit E isoform X6

      UniProtKB/TrEMBL
      I3NI13
    9. XM_047433981.1XP_047289937.1  INO80 complex subunit E isoform X1

    10. XM_024450236.2XP_024306004.1  INO80 complex subunit E isoform X6

      UniProtKB/TrEMBL
      I3NI13
    11. XM_011545811.4XP_011544113.1  INO80 complex subunit E isoform X10

      See identical proteins and their annotated locations for XP_011544113.1

      UniProtKB/TrEMBL
      I3L270
      Related
      ENSP00000461808.1, ENST00000567254.5
    12. XM_047433988.1XP_047289944.1  INO80 complex subunit E isoform X9

    13. XM_047433989.1XP_047289945.1  INO80 complex subunit E isoform X12

      Related
      ENSP00000484187.1, ENST00000620599.4

    RNA

    1. XR_002957798.2 RNA Sequence

    2. XR_007064869.1 RNA Sequence

    3. XR_007064870.1 RNA Sequence

    4. XR_002957799.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      30278881..30288431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380132.1XP_054236107.1  INO80 complex subunit E isoform X3

    2. XM_054380141.1XP_054236116.1  INO80 complex subunit E isoform X11

    3. XM_054380131.1XP_054236106.1  INO80 complex subunit E isoform X2

    4. XM_054380133.1XP_054236108.1  INO80 complex subunit E isoform X4

    5. XM_054380134.1XP_054236109.1  INO80 complex subunit E isoform X5

    6. XM_054380138.1XP_054236113.1  INO80 complex subunit E isoform X8

    7. XM_054380137.1XP_054236112.1  INO80 complex subunit E isoform X7

    8. XM_054380135.1XP_054236110.1  INO80 complex subunit E isoform X6

    9. XM_054380130.1XP_054236105.1  INO80 complex subunit E isoform X1

    10. XM_054380136.1XP_054236111.1  INO80 complex subunit E isoform X6

    11. XM_054380140.1XP_054236115.1  INO80 complex subunit E isoform X10

    12. XM_054380139.1XP_054236114.1  INO80 complex subunit E isoform X9

    13. XM_054380142.1XP_054236117.1  INO80 complex subunit E isoform X12

    RNA

    1. XR_008489077.1 RNA Sequence

    2. XR_008489078.1 RNA Sequence

    3. XR_008489079.1 RNA Sequence

    4. XR_008489080.1 RNA Sequence