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    SLC22A24 solute carrier family 22 member 24 [ Homo sapiens (human) ]

    Gene ID: 283238, updated on 5-Mar-2024

    Summary

    Official Symbol
    SLC22A24provided by HGNC
    Official Full Name
    solute carrier family 22 member 24provided by HGNC
    Primary source
    HGNC:HGNC:28542
    See related
    Ensembl:ENSG00000197658 MIM:611698; AllianceGenome:HGNC:28542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NET46
    Summary
    SLC22A24 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC22A24 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63079940..63144221, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63069241..63133470, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62847412..62911693, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene PTTG1 pseudogene 2 Neighboring gene tubulin alpha pseudogene 7 Neighboring gene ribosomal protein L29 pseudogene 22 Neighboring gene solute carrier family 22 member 25 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:62969965-62970144 Neighboring gene uncharacterized LOC105369334 Neighboring gene cyclin D2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of maternal and inherited loci for conotruncal heart defects.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC34821

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sterol transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    steroid transmembrane transporter SLC22A24

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136506.2NP_001129978.2  steroid transmembrane transporter SLC22A24 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AP001858, KF459672
      Consensus CDS
      CCDS73308.1
      UniProtKB/Swiss-Prot
      A0A087WWM3, C9JC66, Q8N4F4
      Related
      ENSP00000480336.1, ENST00000612278.4
      Conserved Domains (1) summary
      cd17374
      Location:109516
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters
    2. NM_173586.3NP_775857.2  steroid transmembrane transporter SLC22A24 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AP001858, BC034394
      Consensus CDS
      CCDS76422.1
      UniProtKB/Swiss-Prot
      Q8N4F4
      Related
      ENSP00000321549.5, ENST00000326192.5
      Conserved Domains (1) summary
      cd06174
      Location:125278
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      63079940..63144221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      63069241..63133470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)